Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan 1:17:1533034617742311.
doi: 10.1177/1533034617742311.

A Network Meta-Analysis on the Diagnostic Value of Different Imaging Methods for Lymph Node Metastases in Patients With Cervical Cancer

Qian Luo  1 , Lan Luo  2 , Liang Tang  3
Affiliations

A Network Meta-Analysis on the Diagnostic Value of Different Imaging Methods for Lymph Node Metastases in Patients With Cervical Cancer

Qian Luo et al. Technol Cancer Res Treat. .

Abstract

Purpose: We performed this network meta-analysis to compare the diagnostic value of 4 imaging methods (magnetic resonance imaging, positron emission tomography, computed tomography, and diffusion-weighted imaging) for diagnosing lymph node metastases in cervical cancer.

Method: Diagnostic tests regarding different imaging methods to diagnose lymph node metastases in cervical cancer were retrieved from the Cochrane Library, PubMed, and Embase electronic databases from inception to December 2016. Direct and indirect evidence was performed to calculate the odds ratio and to draw the surface under the cumulative ranking curves of the 4 imaging methods for diagnosing lymph node metastases in cervical cancer.

Results: Sixteen eligible diagnostic tests were included in this network meta-analysis. The results of network meta-analysis demonstrate that in comparison with the diffusion-weighted imaging, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of positron emission tomography were relatively higher. Additionally, the results further indicate that compared with other diagnosis method, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of positron emission tomography had a higher trend. The surface under the cumulative ranking curve results indicated that in terms of positive likelihood ratio and diagnostic odds ratio, positron emission tomography had a relatively higher diagnostic value for lymph node metastases in patients with cervical cancer.

Conclusion: Our findings indicate that positron emission tomography might have a relatively higher diagnostic value for lymph node metastases in patients with cervical cancer.

Keywords: cervical cancer; computed tomography; diagnostic tests; lymph node metastases; magnetic resonance imaging.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Quality Assessment of Diagnostic Accuracy Studies (QUADAS) included in the network meta-analysis checklist.
Figure 2.
Figure 2.
Bivariate box plot diagnostic value for 4 imaging methods in the diagnosis of lymph node metastasis in patients with CC. CC indicates cervical cancer.
Figure 3.
Figure 3.
Summary receiver operating characteristic diagram of diagnostic value for 4 imaging methods in the diagnosis of lymph node metastasis in patients with CC. CC indicates cervical cancer.
Figure 4.
Figure 4.
Deek funnel plot of diagnostic value for 4 imaging methods in the diagnosis of lymph node metastasis in patients with CC. CC indicates cervical cancer.
Figure 5.
Figure 5.
Network evidence of the diagnostic value of 4 imaging methods in the diagnosis of lymph node metastasis in patients with CC. CC indicates cervical cancer; CT, computer tomography; DWI, diffusion-weighted imaging; MRI, magnetic resonance imaging; PET, positron emission tomography.
Figure 6.
Figure 6.
Node splitting plot of the diagnostic value of 4 imaging methods in the diagnosis of lymph node metastasis in patients with CC. A, Magnetic resonance imaging. B, Positron emission tomography. C, Computer tomography; D, diffusion-weighted imaging. CC indicates cervical cancer.
See this image and copyright information in PMC

References

    1. Nowakowski A, Sliwczynski A, Seroczynski P, Cybulski M, Teter Z. Reimbursed costs of management of uterine cervical lesions in Poland—a descriptive analysis of data from the National Health Fund and the Ministry of Health. Cent Eur J Public Health. 2016;24(2):163–168. - PubMed
    1. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–E386. - PubMed
    1. Chang B, Kim J, Jeong D, et al. Klotho inhibits the capacity of cell migration and invasion in cervical cancer. Oncol Rep. 2012;28(3):1022–1028. - PubMed
    1. Cheng YM, Chou CY, Hsu Y.C, Chen MJ, Wing LY. The role of human papillomavirus type 16 E6/E7 oncoproteins in cervical epithelial-mesenchymal transition and carcinogenesis. Oncol Lett. 2012;3(3):667–671. - PMC - PubMed
    1. Luhn P, Walker J, Schiffman M, et al. The role of co-factors in the progression from human papillomavirus infection to cervical cancer. Gynecol Oncol. 2013;128(2):265–270. - PMC - PubMed

Publication types

MeSH terms