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Comment
. 2018 Jan 16;48(1):11-13.
doi: 10.1016/j.immuni.2018.01.002.

HIV Immunogens: Affinity Is Key

Savit Prabhu  1 , Ian A Cockburn  1 , Carola G Vinuesa  2
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HIV Immunogens: Affinity Is Key

Savit Prabhu et al. Immunity. .
Free article

Abstract

Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers.

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