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Comment
. 2018 Jan 16;48(1):13-16.
doi: 10.1016/j.immuni.2017.12.011.

A Long-Distance Relay-tionship between Tumor and Bone

Klara Soukup  1 , Johanna A Joyce  2
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Free article
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A Long-Distance Relay-tionship between Tumor and Bone

Klara Soukup et al. Immunity. .
Free article

Abstract

Myeloid cells, including neutrophils, are important regulators of tumor growth and metastasis. In Science, Engblom et al. (2017) reveal how lung tumors remotely engage bone-resident cells through a relay mechanism that achieves a sustained supply of tumor-promoting neutrophils.

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  • Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.
    Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. Engblom C, et al. Science. 2017 Dec 1;358(6367):eaal5081. doi: 10.1126/science.aal5081. Science. 2017. PMID: 29191879 Free PMC article.

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