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Comment
. 2018 Jan 17;38(3):515-517.
doi: 10.1523/JNEUROSCI.2710-17.2017.

New Insights on the Role of Residue 673 of APP in Alzheimer's Disease

Matthew C Mueller  1 , Bradley J Baranowski  2 , Grant C Hayward  2
Affiliations
Comment

New Insights on the Role of Residue 673 of APP in Alzheimer's Disease

Matthew C Mueller et al. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
APP can be cleaved through amyloidogenic or non-amyloidogenic pathways. In the non-amyloidogenic pathway, α-secretase cleaves APP to form sAPPα and CTF83. In the amyloidogenic pathway, APP is cleaved by β-secretase (BACE1) at either the Glu11 site to form CTF89, resulting in a truncated form of Aβ, or the Asp1 site to make CTF99, which is cleaved by γ-secretase to form Aβ (gray). The Ala673 site of APP becomes the Ala2 site (red) of Aβ.
See this image and copyright information in PMC

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