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. 2017 Dec 28:12:35-44.
doi: 10.2147/PPA.S151561. eCollection 2018.

Patient preferences for important attributes of bipolar depression treatments: a discrete choice experiment

Daisy Ng-Mak  1 , Jiat-Ling Poon  2 , Laurie Roberts  2 , Leah Kleinman  2 , Dennis A Revicki  2 , Krithika Rajagopalan  1
Affiliations

Patient preferences for important attributes of bipolar depression treatments: a discrete choice experiment

Daisy Ng-Mak et al. Patient Prefer Adherence. .

Abstract

Purpose: The purpose of this study was to assess patient preferences regarding pharmacological treatment attributes for bipolar depression using a discrete choice experiment (DCE).

Methods: Adult members of an Internet survey panel with a self-reported diagnosis of bipolar depression were invited via e-mail to participate in a web-based DCE survey. Participants were asked to choose between hypothetical medication alternatives defined by attributes and levels that were varied systematically. The six treatment attributes included in the DCE were time to improvement, risk of becoming manic, weight gain, risk of sedation, increased blood sugar, and increased cholesterol. Attributes were supported by literature review, expert input, and results of focus groups with patients. Sawtooth CBC System for Choice-Based Conjoint Analysis was used to estimate the part-worth utilities for the DCE analyses.

Results: The analytical sample included 185 participants (50.8% females) from a total of 200 participants. The DCE analyses found weight gain to be the most important treatment attribute (relative importance =49.6%), followed by risk of sedation (20.2%), risk of mania (13.0%), increased blood sugar (8.3%), increased cholesterol (5.2%), and time to improvement (3.7%).

Conclusion: Results from this DCE suggest that adults with bipolar depression considered risks of weight gain and sedation associated with pharmacotherapy as the most important attributes for the treatment of bipolar depression. Incorporating patient preferences in the treatment decision-making process may potentially have an impact on treatment adherence and satisfaction and, ultimately, patient outcomes.

Keywords: adverse events; bipolar depression; treatment preference; weight gain.

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Conflict of interest statement

Disclosure DN-M and KR are full-time employees of Sunovion Pharmaceuticals Inc. J-LP, LR, LK, and DAR are full-time employees of Evidera. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
DCE question sample. Abbreviation: DCE, discrete choice experiment.
Figure 2
Figure 2
Part-worth utility values (N=185). Notes: Part-worth utility values scaled within each attribute to have a mean of 0. Positive part-worth utility value indicates that the attribute level is preferred over levels with negative values. Larger part-worth utility values indicate a higher degree of preference for one level over another. Error bars denote standard errors. Abbreviation: RI, relative importance.
See this image and copyright information in PMC

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