Insulin Resistance in Kidney Disease: Is There a Distinct Role Separate from That of Diabetes or Obesity?

Abstract

Insulin resistance is a central component of the metabolic dysregulation observed in obesity, which puts one at risk for the development of type 2 diabetes and complications related to diabetes such as chronic kidney disease. Insulin resistance and compensatory hyperinsulinemia place one at risk for other risk factors such as dyslipidemia, hypertension, and proteinuria, e.g., development of kidney disease. Our traditional view of insulin actions focuses on insulin-sensitive tissues such as skeletal muscle, liver, adipose tissue, and the pancreas. However, insulin also has distinct actions in kidney tissue that regulate growth, hypertrophy, as well as microcirculatory and fibrotic pathways which, in turn, impact glomerular filtration, including that governed by tubuloglomerular feedback. However, it is often difficult to discern the distinct effects of excess circulating insulin and impaired insulin actions, as exist in the insulin resistance individual, from the associated effects of obesity or elevated systolic blood pressure on the development and progression of kidney disease over time. Therefore, we review the experimental and clinical evidence for the distinct impact of insulin resistance on kidney function and disease.

Keywords: Chronic kidney disease; Insulin resistance; Renin-angiotensin-aldosterone system.

Fig. 1

The distinct role for insulin resistance and insulin actions in the kidney. The development of hyperinsulinemia in insulin resistance has a role in the development of kidney injury separate from that of obesity and the development of type 2 diabetes. FGS, focal glomerulosclerosis; GFR, glomerular filtration rate; NO, nitric oxide; RAAS, renin-angiotensin-aldosterone system; RPF, renal plasma flow.