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Review
. 2018 Jan 1;9(2):232-238.
doi: 10.7150/jca.22962. eCollection 2018.

Interferon-γ and Colorectal Cancer: an up-to date

Christoforos Kosmidis  1 , Konstantinos Sapalidis  1 , Triantafyllia Koletsa  2 , Maria Kosmidou  3 , Christoforos Efthimiadis  4 , George Anthimidis  4 , Nikolaos Varsamis  1 , Nikolaos Michalopoulos  1 , Charilaos Koulouris  1 , Stefanos Atmatzidis  1 , Lazaros Liavas  1 , Titika-Marina Strati  1 , Georgios Koimtzis  1 , Alexandros Tsakalidis  1 , Stylianos Mantalovas  1 , Katerina Zarampouka  2 , Maria Florou  1 , Dimitrios E Giannakidis  1 , Eleni Georgakoudi  1 , Sofia Baka  5 , Paul Zarogoulidis  6 , Yan-Gao Man  7 , Isaac Kesisoglou  1
Affiliations
Review

Interferon-γ and Colorectal Cancer: an up-to date

Christoforos Kosmidis et al. J Cancer. .

Abstract

Colorectal cancer still remains the third cause of cancer death among cancer patients. Early diagnosis is crucial and they can be either endoscopic or with blood biomarkers. Endoscopic methods consist of gastroscopy and colonoscopy, however; in recent years, endoscopic ultrasound is being used. The microenvironment is very important for the successful delivery of the treatment. Several proteins and hormones play a crucial role in the efficiency of the treatment. In the current mini review we will focus on interferon-γ.

Keywords: colorectal cancer; interferon-γ.; microenvironment.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
The enhanced permeability and retention effect (EPR effect), hypoxia, carcinoma associated fibroblasts (CAFs), Myeloid-derived suppressor cells (MDSCs), Tumor infiltrating lymphocytes (TILs), extracellular matrix remodeling, relation to T cells, apoptosis, reproduction
Figure 2
Figure 2
Treatment options and algorithm
Figure 3
Figure 3
Chemical structure of interferon-γ and sequence
See this image and copyright information in PMC

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