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Review
. 2018 Jan 1;9(2):375-388.
doi: 10.7150/jca.21044. eCollection 2018.

miR-149 in Human Cancer: A Systemic Review

Yunjie He  1 , Dandan Yu  2 , Lingping Zhu  1 , Shanliang Zhong  2 , Jianhua Zhao  2 , Jinhai Tang  1   3
Affiliations
Review

miR-149 in Human Cancer: A Systemic Review

Yunjie He et al. J Cancer. .

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that regulate post-transcriptional gene expression via binding to the 3'-untranslated region (3'-UTR) of targeted mRNAs. They are reported to play important roles in tumorigenesis and progression of various cancers. Among them, miR-149 was confirmed to be aberrantly regulated in various tumors. In this review, we provide a complex overview of miR-149, particularly summarize the critical roles of it in cancers and expect to lay the foundation for future works on this important microRNA.

Keywords: cancer.; miR-149; miRNA.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Structure, targeted genes and pathways of miR-149. (A): The predicted stem-loop structure of miR-149 determined using the RNA structure software. (B): The sequence of miR-149. (C, D): The targeted genes and pathways potentially affected by miR-149-5p and miR-149-3p identified using the Diana-MicroT and TagetScan tools.
Figure 1
Figure 1
Structure, targeted genes and pathways of miR-149. (A): The predicted stem-loop structure of miR-149 determined using the RNA structure software. (B): The sequence of miR-149. (C, D): The targeted genes and pathways potentially affected by miR-149-5p and miR-149-3p identified using the Diana-MicroT and TagetScan tools.
Figure 1
Figure 1
Structure, targeted genes and pathways of miR-149. (A): The predicted stem-loop structure of miR-149 determined using the RNA structure software. (B): The sequence of miR-149. (C, D): The targeted genes and pathways potentially affected by miR-149-5p and miR-149-3p identified using the Diana-MicroT and TagetScan tools.
Figure 2
Figure 2
Dual roles of miR-149-5p and miR-149-3p in proliferation and apoptosis. (A): miR-149-5p. (B): miR-149-3p.
Figure 3
Figure 3
miR-149-5p found to be an important tumor suppressor of metastasis.
Figure 4
Figure 4
miR-149-5p and miR-149-3p confirmed to increase drug sensitivity.
Figure 5
Figure 5
miR-149-3p and miR-149-5p participate in tumor microenvironment. (A) miR-149-5p mediates the crosstalk between tumor cells and CAFs: H. pylori infection leads to induce PGE2 signaling and result in reduction of miR-149-5p in CAFs and increase IL-6 secretion. (B) Overexpression of miR-149-5p or miR-149-3p alleviated FGF2 signaling in endothelial cells and reduced neovascularization via targeting GPC1 and FGFR1.
See this image and copyright information in PMC

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