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. 2017 Dec 17;4(2):e000702.
doi: 10.1136/openhrt-2017-000702. eCollection 2017.

Prevalence and prognostic value of echocardiographic screening for rheumatic heart disease

Susy Kotit  1   2   3 , Karim Said  2   4 , Amr ElFaramawy  2   4 , Hani Mahmoud  2 , David I W Phillips  5 , Magdi H Yacoub  1   2   3
Affiliations

Prevalence and prognostic value of echocardiographic screening for rheumatic heart disease

Susy Kotit et al. Open Heart. .

Abstract

Objective: Rheumatic heart disease (RHD) remains a major health problem in many low-income and middle-income countries. The use of echocardiographic imaging suggests that subclinical disease is far more widespread than previously appreciated, but little is known as to how these mild forms of RHD progress. We have determined the prevalence of subclinical RHD in a large group of schoolchildren in Aswan, Egypt and have evaluated its subsequent progression.

Methods: Echocardiographic screening was performed on 3062 randomly selected schoolchildren, aged 5-15 years, in Aswan, Egypt. Follow-up of children with a definite or borderline diagnosis of RHD was carried out 48-60 months later to determine how the valvular abnormalities altered and to evaluate the factors influencing progression.

Results: Sixty children were initially diagnosed with definite RHD (19.6 per 1000 children) and 35 with borderline disease (11.4 per 1000); most had mitral valve disease. Of the 72 children followed up progression was documented in 14 children (19.4%) and regression in 30 (41.7%) children. Boys had lower rates of progression while older children had lower rates of regression. Functional defects of the valve even in the presence of structural features were associated with lower rates of progression and higher rates of regression than structural changes.

Conclusions: RHD has a high prevalence in Egypt. Although a high proportion of the abnormalities originally detected persisted at follow-up, both progression and regression of valve lesions were demonstrated.

Keywords: echocardiography; epidemiology; rheumatic heart disease.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Location of Aswan, Egypt, and the city’s seven geographical areas.
See this image and copyright information in PMC

References

    1. Remenyi B, ElGuindy A, Smith SC, et al. . Valvular aspects of rheumatic heart disease. Lancet 2016;387:1335–46. 10.1016/S0140-6736(16)00547-X - DOI - PubMed
    1. Carapetis JR, Beaton A, Cunningham MW, et al. . Acute rheumatic fever and rheumatic heart disease. Nat Rev Dis Primers 2016;2:15084 10.1038/nrdp.2015.84 - DOI - PMC - PubMed
    1. Engelman D, Kado JH, Reményi B, et al. . Focused cardiac ultrasound screening for rheumatic heart disease by briefly trained health workers: a study of diagnostic accuracy. Lancet Glob Health 2016;4:e386–394. 10.1016/S2214-109X(16)30065-1 - DOI - PubMed
    1. Roberts KV, Maguire GP, Brown A, et al. . Rheumatic heart disease in Indigenous children in northern Australia: differences in prevalence and the challenges of screening. Med J Aust 2015;203:221 10.5694/mja15.00139 - DOI - PubMed
    1. World Heart Federation. Rheumatic heart disease. Geneva, Switzerland: https://www.world-heart-federation.org/programmes/rheumatic-heart-disease

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