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Review
. 2018 Jun;50(3):189-198.
doi: 10.1007/s10863-018-9742-3. Epub 2018 Jan 18.

O-GlcNAcylation: key regulator of glycolytic pathways

Zachary A Bacigalupa  1 , Chaitali H Bhadiadra  1 , Mauricio J Reginato  2
Affiliations
Review

O-GlcNAcylation: key regulator of glycolytic pathways

Zachary A Bacigalupa et al. J Bioenerg Biomembr. 2018 Jun.

Abstract

Elevated O-GlcNAcylation is emerging as a general characteristic of most cancers. Although O-GlcNAcylation can regulate many cell biological pathways, recent evidence suggests that it is a key regulator of metabolic pathways including glycolysis in cancer cells. This review summarizes our current understanding of how O-GlcNAcylation regulates glycolytic pathways and contributes to alterations in cancer cell metabolism.

Keywords: Cancer; Glycolysis; Metabolism; O-GlcNAc transferase; O-GlcNAcylation.

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Figures

Fig. 1
Fig. 1. O-GlcNAcylated proteins involved in glycolysis, PPP, TCA cycle and glutamine metabolism.
All enzymes marked with G have been shown to be O-GlcNAcylated
See this image and copyright information in PMC

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