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. 1986 Jan;57(1):362-6.
doi: 10.1128/JVI.57.1.362-366.1986.

Interferon-induced gene expression in wild-type and interferon-resistant human lymphoblastoid (Daudi) cells

M McMahon, G R Stark, I M Kerr

Interferon-induced gene expression in wild-type and interferon-resistant human lymphoblastoid (Daudi) cells

M McMahon et al. J Virol. 1986 Jan.

Abstract

Interferon-induced gene expression was analyzed in wild-type and interferon-resistant Daudi cells. Two classes of alpha-interferon-induced mRNAs and proteins were observed: those that were similarly induced in both types of cell and those that were induced only in the wild-type cells. Furthermore, the level of c-myc mRNA decreased in the wild-type but not in the resistant cells. This differential control in the wild-type and resistant cells indicates that there must be either functionally distinct alpha-interferon receptors or more than one pathway leading to altered gene expression triggered by a single receptor.

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