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Review
. 2018 Apr;30(2):182-186.
doi: 10.1097/MOP.0000000000000589.

Neonatal abstinence syndrome: an update

Lauren A Sanlorenzo  1   2 , Ann R Stark  1   2 , Stephen W Patrick  1   2   3   4
Affiliations
Review

Neonatal abstinence syndrome: an update

Lauren A Sanlorenzo et al. Curr Opin Pediatr. 2018 Apr.

Abstract

Purpose of review: The current review provides an update focused on the evolving epidemiology of neonatal abstinence syndrome (NAS), factors influencing disease expression, advances in clinical assessment of withdrawal, novel approaches to NAS treatment, and the emerging role of quality improvement in assessment and management of NAS.

Recent findings: The rise in the incidence of NAS disproportionately occurred in rural and suburban areas. Polysubstance exposure and genetic polymorphisms have been shown to modify NAS expression and severity. New bedside assessments using a limited number of factors to identify infants with NAS result in fewer infants receiving pharmacotherapy. In addition, buprenorphine may be a promising therapeutic alternative to morphine to treat NAS. Lastly, local, state, and national quality improvement initiatives have emerged as an effective mechanism to advance the care of infants with NAS.

Summary: NAS remains a critical public health issue associated with significant medical, economic, and personal burdens. Emerging data on associated risk factors, assessment of and treatment for NAS provide clinicians and hospitals with new knowledge and an urgency to promote standardization of care for infants with NAS.

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Conflict of interest statement

Conflicts of interest: The authors have no financial disclosures or conflicts of interest in relation to this work.

References

    1. Patrick SW, Davis MM, Lehman CU, Cooper WO. Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012. J Perinatol. 2015;35(8):667. - PubMed
    1. Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM. Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009. Jama. 2012;307(18):1934–40. - PubMed
    1. Finnegan LP, Connaughton JF, Jr, Kron RE, Emich JP. Neonatal abstinence syndrome: assessment and management. Addictive diseases. 1975;2(1-2):141–58. - PubMed
    1. Jackson L, Ting A, McKay S, Galea P, Skeoch C. A randomised controlled trial of morphine versus phenobarbitone for neonatal abstinence syndrome. Archives of disease in childhood Fetal and neonatal edition. 2004;89(4):F300–4. - PMC - PubMed
    1. Hall ES, Wexelblatt SL, Crowley M, Grow JL, Jasin LR, Klebanoff MA, et al. A multicenter cohort study of treatments and hospital outcomes in neonatal abstinence syndrome. Pediatrics. 2014;134(2):e527–34. - PMC - PubMed

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