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. 2018 Jan 18;12(1):e0006153.
doi: 10.1371/journal.pntd.0006153. eCollection 2018 Jan.

Geographical distribution of soil transmitted helminths and the effects of community type in South Asia and South East Asia - A systematic review

Zachary A Silver  1 , Saravanakumar P Kaliappan  2 , Prasanna Samuel  2   3 , Srinivasan Venugopal  2 , Gagandeep Kang  2 , Rajiv Sarkar  2 , Sitara S R Ajjampur  2
Affiliations

Geographical distribution of soil transmitted helminths and the effects of community type in South Asia and South East Asia - A systematic review

Zachary A Silver et al. PLoS Negl Trop Dis. .

Abstract

Background: Soil-transmitted helminth (STH) infections are among the most prevalent neglected tropical diseases (NTD) worldwide. Since the publication of the WHO road map to combat NTD in 2012, there has been a renewed commitment to control STH. In this study, we analysed the geographical distribution and effect of community type on prevalence of hookworm, Trichuris and Ascaris in south Asia and south east Asia.

Methodology: We conducted a systematic review of open-access literature published in PubMed Central and the Global Atlas of Helminth Infection. A total of 4182 articles were available and after applying selection criteria, 174 studies from the region were retained for analysis.

Principal findings: Ascaris was the commonest STH identified with an overall prevalence of 18% (95% CI, 14-23%) followed by Trichuris (14%, 9-19%) and hookworm (12%, 9-15%). Hookworm prevalence was highest in Laos, Vietnam and Cambodia. We found a geographical overlap in countries with high prevalence rates for Trichuris and Ascaris (Malaysia, Philippines, Myanmar, Vietnam and Bangladesh). When the effect of community type was examined, prevalence rates of hookworm was comparable in rural (19%, 14-24%) and tribal communities (14%, 10-19%). Tribal communities, however, showed higher prevalence of Trichuris (38%, 18-63%) and Ascaris (32%, 23-43%) than rural communities (13%, 9-20% and 14%, 9-20% respectively). Considerable between and within country heterogeneity in the distribution of STH (I2 >90%) was also noted. When available data from school aged children (SAC) were analysed, prevalence of Ascaris (25% 16-31%) and Trichuris (22%, 14-34%) were higher than among the general population while that of hookworm (10%, 7-16%) was comparable.

Conclusions/significance: Our analysis showed significant variation in prevalence rates between and within countries in the region. Highlighting the importance of community type in prevalence and species mix, we showed that tribal and rural communities had higher hookworm infections than urban communities and for ascariasis and trichuriasis, tribal populations had higher levels of infection than rural populations. We also found a higher prevalence of ascariasis and trichuriasis in SAC compared to the general population but comparable levels of hookworm infections. These key findings need to be taken into account in planning future MDA and other interventions.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. PRISMA flow diagram.
Fig 2
Fig 2. Prevalence of Hookworm in South and South East Asia by Country.
Fig 3
Fig 3. Prevalence of Trichuris in South and South East Asia by Country.
Fig 4
Fig 4. Prevalence of Ascaris in South and South East Asia by Country.
Fig 5
Fig 5. Prevalence of soil transmitted Helminths in South and South East Asia by community type in the general population.
Fig 6
Fig 6. Prevalence of soil transmitted Helminths in South and South East Asia by Community type in School Aged Children.
See this image and copyright information in PMC

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