doi: 10.1002/j.1875-9114.1985.tb03434.x.
Amiodarone: pharmacology and antiarrhythmic and adverse effects
- PMID: 2934688
- DOI: 10.1002/j.1875-9114.1985.tb03434.x
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Amiodarone: pharmacology and antiarrhythmic and adverse effects
Pharmacotherapy.
1985 Nov-Dec.
Abstract
Amiodarone is a benzofuran derivative that has been effective for the treatment of both supraventricular and ventricular tachyarrhythmias. It has a large volume of distribution, moderate bioavailability and a long half-life. Its pharmacokinetics are not well understood and its tissue distribution is not typical of a 2-compartment model. Due to ocular, dermatologic, gastrointestinal, neurologic, cardiovascular, thyroid and pulmonary toxicity, amiodarone should be reserved for use in patients with refractory and/or life-threatening arrhythmias.
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