Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Nov-Dec;5(6):298-313.
doi: 10.1002/j.1875-9114.1985.tb03434.x.

Amiodarone: pharmacology and antiarrhythmic and adverse effects

G V Naccarelli, R L Rinkenberger, A H Dougherty, R A Giebel

Amiodarone: pharmacology and antiarrhythmic and adverse effects

G V Naccarelli et al. Pharmacotherapy. 1985 Nov-Dec.

Abstract

Amiodarone is a benzofuran derivative that has been effective for the treatment of both supraventricular and ventricular tachyarrhythmias. It has a large volume of distribution, moderate bioavailability and a long half-life. Its pharmacokinetics are not well understood and its tissue distribution is not typical of a 2-compartment model. Due to ocular, dermatologic, gastrointestinal, neurologic, cardiovascular, thyroid and pulmonary toxicity, amiodarone should be reserved for use in patients with refractory and/or life-threatening arrhythmias.

PubMed Disclaimer

MeSH terms

LinkOut - more resources