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. 1985 Dec;82(24):8729-32.
doi: 10.1073/pnas.82.24.8729.

Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related

C W Wong, V Quaranta, G G Glenner

Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related

C W Wong et al. Proc Natl Acad Sci U S A. 1985 Dec.

Abstract

A synthetic peptide (Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr), homologous to the amino terminus of a protein purified from cerebrovascular amyloid (beta protein), induced antibodies in BALB/c mice that were used immunohistochemically to stain not only amyloid-laden cerebral vessels but neuritic plaques as well. These findings suggest that the amyloid in neuritic plaques shares antigenic determinants with beta protein of cerebral vessels. Since the amino acid compositions of plaque amyloid and cerebrovascular amyloid are similar, it is likely that plaque amyloid also consists of beta protein. This possibility suggests a model for the pathogenesis of Alzheimer disease involving beta protein.

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References

    1. Nature. 1966 Jan 1;209(5018):109-10 - PubMed
    1. Lancet. 1985 Feb 2;1(8423):278 - PubMed
    1. J Neuropathol Exp Neurol. 1973 Oct;32(4):566-84 - PubMed
    1. Acta Neuropathol. 1976 Nov 15;36(3):243-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4499-503 - PubMed

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