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Comment
. 2018 Feb;19(2):102-103.
doi: 10.1038/s41590-017-0031-9.

Trials and Tribble-ations of tissue TRM cells

Jun Siong Low  1 , Susan M Kaech  2
Affiliations
Comment

Trials and Tribble-ations of tissue TRM cells

Jun Siong Low et al. Nat Immunol. 2018 Feb.

Abstract

CD8+ tissue-resident memory T cells (TRM cells) in two mucosal tissues, the skin and the female reproductive tract, proliferate in situ to generate a secondary pool of TRM cells that does not exit into the circulation.

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Conflict of interest statement

Competing interests

The authors declare no competing financial interests.

Figures

Fig. 1 |
Fig. 1 |. Effects of secondary infection on a pre-existing TRM cell population.
CD8+ TRM cells (green) are motile sentinels that patrol and survey their tissue microenvironments for reinfection. When they recognize their target antigen (Ag) during reinfection, CD8+ TRM cells arrest and undergo in situ proliferation to generate a secondary pool of TRM cells that does not exit into the circulation. Antigen-specific (purple) and bystander (blue) CD8+ TCIRC cells are also recruited into the infected tissue and adopt long-term tissue residency without displacing the pre-existing TRM cells, thereby increasing the number and repertoire of TRM cells in the tissue. Credit: Marina Spence/Springer Nature
See this image and copyright information in PMC

Comment on

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