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Clinical Trial
. 2017:2017:4265091.
doi: 10.1155/2017/4265091. Epub 2017 Dec 4.

Treatment of Anemia of Chronic Disease with True Iron Deficiency in Pregnancy

Gabriela Amstad Bencaiova  1 , Alexander Krafft  2 , Roland Zimmermann  2 , Tilo Burkhardt  2
Affiliations
Clinical Trial

Treatment of Anemia of Chronic Disease with True Iron Deficiency in Pregnancy

Gabriela Amstad Bencaiova et al. J Pregnancy. 2017.

Abstract

Objective: We assess and compare the efficacy of anemia treatment in pregnant women with anemia of chronic disease with true iron deficiency and in women with iron deficiency anemia.

Study design: Fifty patients with moderate anemia (hemoglobin 8.0-9.9 g/dl) and iron deficiency (ferritin < 15 μg/l) were treated in the Anemia Clinic at the Department of Obstetrics.

Results: All patients showed stimulation of erythropoiesis as evidenced by an increase in reticulocyte count at day eight of therapy and showed an increase in hemoglobin and hematocrit at the end of therapy (p < 0.001). The target hemoglobin (≥10.5 g/dl) was achieved in 45/50 women (90%). 12 patients showed anemia of chronic disease with true iron deficiency (12/50; 24%). Seven women (7/12; 59%) with anemia of chronic disease and iron deficiency responded well to anemia treatment. 50% of women with anemia of chronic disease and iron deficiency (3/6) responded well to intravenous iron, and 67% (4/6) responded well to the combination of intravenous iron and recombinant human erythropoietin.

Conclusion: Because of frequent true iron deficiency in pregnant women with anemia of chronic disease, anemia of chronic disease in pregnancy is often falsely diagnosed as iron deficiency anemia.

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Figures

Figure 1
Figure 1
Therapy protocol.
Figure 2
Figure 2
Course of Hb during therapy at the start and the end of the treatment.
Figure 3
Figure 3
Respective MRC levels at the start and the end of the treatment.
Figure 4
Figure 4
Respective HRC levels at the start and the end of the treatment.
See this image and copyright information in PMC

References

    1. DeMaeyer E., Adiels-Tegman M. The prevalence of anaemia in the world. World Health Statistics Quarterly. 1985;38(3):302–316. - PubMed
    1. Viteri F. E. The consequences of iron deficiency and anaemia in pregnancy on maternal health, the foetus and the infant. SCN News. 1994;(11):14–18. - PubMed
    1. Scholl T. O. Iron status during pregnancy: setting the stage for mother and infant. American Journal of Clinical Nutrition. 2005;81:1218S–1222S. - PubMed
    1. Scholl T. O., Reilly T. iron and pregnancy outcome. Journal of Nutrition. 2000;130:443S–447S. - PubMed
    1. Levy A., Fraser D., Katz M., Mazor M., Sheiner E. Maternal anemia during pregnancy is an independent risk factor for low birthweight and preterm delivery. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2005;122(2):182–186. doi: 10.1016/j.ejogrb.2005.02.015. - DOI - PubMed

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