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Review
. 2018 Jan 8:13:63-72.
doi: 10.1016/j.bbrep.2017.12.002. eCollection 2018 Mar.

Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles

Rakesh M Patil  1   2 , Nanasaheb D Thorat  3 , Prajkta B Shete  2 , Poonam A Bedge  4 , Shambala Gavde  2 , Meghnad G Joshi  4 , Syed A M Tofail  3 , Raghvendra A Bohara  2   4   5
Affiliations
Review

Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles

Rakesh M Patil et al. Biochem Biophys Rep. .

Abstract

Recently lots of efforts have been taken to develop superparamagnetic iron oxide nanoparticles (SPIONs) for biomedical applications. So it is utmost necessary to have in depth knowledge of the toxicity occurred by this material. This article is designed in such way that it covers all the associated toxicity issues of SPIONs. It mainly emphasis on toxicity occurred at different levels including cellular alterations in the form of damage to nucleic acids due to oxidative stress and altered cellular response. In addition focus is been devoted for in vitro and in vivo toxicity of SPIONs, so that a better therapeutics can be designed. At the end the time dependent nature of toxicity and its ultimate faith inside the body is being discussed.

Keywords: Biomedical applications; Cellular alteration; SPIONs; Toxicity.

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Figures

Fig. 1
Fig. 1
Schematic representation of possible mechanism of SPIONs interaction and SPIONs-induced toxicity at cellular level.
See this image and copyright information in PMC

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