Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2018 Feb 5;33(6):e45.
doi: 10.3346/jkms.2018.33.e45.

Etiology of Invasive Bacterial Infections in Immunocompetent Children in Korea (2006-2010): a Retrospective Multicenter Study

Kyuyol Rhie  1 , Eun Hwa Choi  1   2 , Eun Young Cho  2   3 , Jina Lee  4 , Jin Han Kang  5 , Dong Soo Kim  6 , Yae Jean Kim  7 , Youngmin Ahn  8 , Byung Wook Eun  8 , Sung Hee Oh  9 , Sung Ho Cha  10 , Young Jin Hong  11 , Kwang Nam Kim  12 , Nam Hee Kim  13 , Yun Kyung Kim  14 , Jong Hyun Kim  15 , Taekjin Lee  16 , Hwang Min Kim  17 , Kun Song Lee  18 , Chun Soo Kim  19 , Su Eun Park  20 , Young Mi Kim  20 , Chi Eun Oh  21 , Sang Hyuk Ma  22 , Dae Sun Jo  23 , Young Youn Choi  24 , Hoan Jong Lee  1   25
Affiliations
Multicenter Study

Etiology of Invasive Bacterial Infections in Immunocompetent Children in Korea (2006-2010): a Retrospective Multicenter Study

Kyuyol Rhie et al. J Korean Med Sci. .

Erratum in

Abstract

Background: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea.

Methods: A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005.

Results: Escherichia coli (41.3%), Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) were the most common pathogens in infants < 3 months of age. S. agalactiae was the most prevalent cause of meningitis and pneumonia and E. coli was the major cause of bacteremia without localizing signs in this group. In children 3 to 59 months of age, Streptococcus pneumoniae (54.2%), S. aureus (20.5%), and Salmonella spp. (14.4%) were the most common pathogens. S. pneumoniae was the leading cause of pneumonia (86.0%), meningitis (65.0%), and bacteremia without localizing signs (49.0%) in this group. In children ≥ 5 years of age, S. aureus (62.8%) was the predominant pathogen, followed by Salmonella species (12.4%) and S. pneumoniae (11.5%). Salmonella species (43.0%) was the most common cause of bacteremia without localizing signs in this group. The relative proportion of S. aureus increased significantly over the 15-year period (1996-2010) in children ≥ 3 months of age (P < 0.001), while that of Haemophilus influenzae decreased significantly in both < 3 months of age group (P = 0.036) and ≥ 3 months of age groups (P < 0.001).

Conclusion: S. agalactiae, E. coli, S. pneumoniae, and S. aureus are common etiologic agents of invasive bacterial infections in Korean children.

Keywords: Bacterial Infections; Epidemiology; Escherichia coli; Staphylococcus aureus; Streptococcus agalactiae; Streptococcus pneumoniae.

PubMed Disclaimer

Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1
Geographic distribution of the 25 university-affiliated hospitals that participated in this study.
Fig. 2
Fig. 2
Distribution of the causative bacterial organisms in invasive infections in immunocompetent Korean children between 2006 and 2010 according to age group and clinical spectrum.
Fig. 3
Fig. 3
Temporal changes in the relative proportions of the 8 most important bacterial organisms of invasive infections in immunocompetent Korean children 3 months of age or older between 1996 and 2010.
See this image and copyright information in PMC

References

    1. Nam SG, Lee HJ. Etiology of invasive bacterial infections in apparently healthy children. Korean J Infect Dis. 1998;30(3):227–234.
    1. Lee JH, Song EK, Lee JA, Kim NH, Kim DH, Park KW, et al. Clinical entities and etiology of invasive bacterial infections in apparently healthy children. Korean J Pediatr. 2005;48(11):1193–1200.
    1. Schuchat A, Hilger T, Zell E, Farley MM, Reingold A, Harrison L, et al. Active bacterial core surveillance of the emerging infections program network. Emerg Infect Dis. 2001;7(1):92–99. - PMC - PubMed
    1. Zakikhany K, Degail MA, Lamagni T, Waight P, Guy R, Zhao H, et al. Increase in invasive Streptococcus pyogenes and Streptococcus pneumoniae infections in England, December 2010 to January 2011. Euro Surveill. 2011;16(5):19785. - PubMed
    1. Infectious agents surveillance report. [Updated 2017]. [Accessed April 30, 2017]. http://www.niid.go.jp/niid/en/iasr-e.html.

Publication types