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Observational Study
. 2018 Mar;12(2):299-303.
doi: 10.1111/irv.12538. Epub 2018 Feb 2.

Species-specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults

Monique Bouvier  1 , Wei-Ju Chen  2   3 , John C Arnold  4 , Mary P Fairchok  2   3   5 , Patrick J Danaher  6 , Tahaniyat Lalani  2   3 , Leslie Malone  7 , Deepika Mor  2   3 , Michelande Ridoré  8 , Timothy H Burgess  2 , Eugene V Millar  2   3
Affiliations
Observational Study

Species-specific clinical characteristics of human coronavirus infection among otherwise healthy adolescents and adults

Monique Bouvier et al. Influenza Other Respir Viruses. 2018 Mar.

Abstract

Human coronavirus (HCoV) is a known cause of influenza-like illness (ILI). In a multisite, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR-positive for HCoV. The distribution of species was as follows: HCoV-OC43 (34%), HCoV-229E (28%), HCoV-NL63 (22%), and HCoV-HKU1 (16%). We did not observe species-specific differences in the clinical characteristics of HCoV infection, with the exception of HCoV-HKU1, for which the severity of gastrointestinal symptoms trended higher on the fourth day of illness.

Keywords: clinical characteristics; coronavirus; influenza-like illness.

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Figures

Figure 1
Figure 1
Median composite severity score by symptom category, study day, and human coronavirus species
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