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Clinical Trial
. 1986 Jan;104(1):69-70.
doi: 10.1001/archopht.1986.01050130079024.

Abnormal retinal function associated with fenretinide, a synthetic retinoid

M I Kaiser-Kupfer, G L Peck, R C Caruso, M J Jaffe, J J DiGiovanna, E G Gross
Clinical Trial

Abnormal retinal function associated with fenretinide, a synthetic retinoid

M I Kaiser-Kupfer et al. Arch Ophthalmol. 1986 Jan.

Abstract

Five patients with basal cell carcinoma received fenretinide. Two patients while receiving the drug had evidence of abnormal rod photoreceptor function that reversed rapidly on cessation of therapy. We speculate that fenretinide may interfere with the binding of vitamin A to opsin or with the transport of vitamin A.

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