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Meta-Analysis
. 2018 Jan 19;22(1):11.
doi: 10.1186/s13054-017-1883-y.

Glycaemic control targets after traumatic brain injury: a systematic review and meta-analysis

Jeroen Hermanides  1   2 , Mark P Plummer  3 , Mark Finnis  4 , Adam M Deane  5 , Jonathan P Coles  6 , David K Menon  6
Affiliations
Meta-Analysis

Glycaemic control targets after traumatic brain injury: a systematic review and meta-analysis

Jeroen Hermanides et al. Crit Care. .

Abstract

Background: Optimal glycaemic targets in traumatic brain injury (TBI) remain unclear. We performed a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing intensive with conventional glycaemic control in TBI requiring admission to an intensive care unit (ICU).

Methods: We systematically searched MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials to November 2016. Outcomes of interest included ICU and in-hospital mortality, poor neurological outcome, the incidence of hypoglycaemia and infective complications. Data were analysed by pairwise random effects models with secondary analysis of differing levels of conventional glycaemic control.

Results: Ten RCTs, involving 1066 TBI patients were included. Three studies were conducted exclusively in a TBI population, whereas in seven trials, the TBI population was a sub-cohort of a mixed neurocritical or general ICU population. Glycaemic targets with intensive control ranged from 4.4 to 6.7 mmol/L, while conventional targets aimed to keep glucose levels below thresholds of 8.4-12 mmol/L. Conventional versus intensive control showed no association with ICU or hospital mortality (relative risk (RR) (95% CI) 0.93 (0.68-1.27), P = 0.64 and 1.07 (0.84-1.36), P = 0.62, respectively). The risk of a poor neurological outcome was higher with conventional control (RR (95% CI) = 1.10 (1.001-1.24), P = 0.047). However, severe hypoglycaemia occurred less frequently with conventional control (RR (95% CI) = 0.22 (0.09-0.52), P = 0.001).

Conclusions: This meta-analysis of intensive glycaemic control shows no association with reduced mortality in TBI. Intensive glucose control showed a borderline significant reduction in the risk of poor neurological outcome, but markedly increased the risk of hypoglycaemia. These contradictory findings should motivate further research.

Keywords: Glucose control; Glycaemia; Intensive insulin therapy; Systematic review; Traumatic brain injury.

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The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Flow chart of study selection
Fig. 2
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Risk of bias summary
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Fig. 3
ICU mortality. RR, relative risk
Fig. 4
Fig. 4
Poor neurological outcome. RR, relative risk
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Fig. 5
Severe hypoglycaemic events. RR, relative risk
Fig. 6
Fig. 6
Moderate hypoglycaemic events. RR, relative risk
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References

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