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. 2018 Jan 18;25(1):4-6.
doi: 10.1016/j.chembiol.2018.01.004.

Try Me: Promiscuous Inhibitors Still Allow for Selective Targeted Protein Degradation

Matthias P Müller  1 , Daniel Rauh  2
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Try Me: Promiscuous Inhibitors Still Allow for Selective Targeted Protein Degradation

Matthias P Müller et al. Cell Chem Biol. .
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Abstract

In this issue of Cell Chemical Biology, Bondeson et al. (2018), Burslem et al. (2018), and Huang et al. (2018) systematically characterize proteolysis-targeting chimeras (PROTACs) regarding their specificity and general advantages of targeted proteolysis of cellular proteins and provide interesting insights into possible future developments.

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