Comment
doi: 10.1016/j.molcel.2017.12.033.
No Excess Baggage: New Life Starts with a Clean Slate
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- PMID: 29351841
- DOI: 10.1016/j.molcel.2017.12.033
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No Excess Baggage: New Life Starts with a Clean Slate
Mol Cell.
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Free article
Abstract
A new mechanism for clearing protein damage from maturing oocytes has been described in a recent study by Bohnert and Kenyon (2017), who demonstrated that sperm-secreted hormones activate a vascular H+-ATPase pump that acidifies lysosomes and thus restores protein homeostasis.
Copyright © 2017 Elsevier Inc. All rights reserved.
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A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage.Nature. 2017 Nov 30;551(7682):629-633. doi: 10.1038/nature24620. Epub 2017 Nov 22. Nature. 2017. PMID: 29168500 Free PMC article.
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