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Comment
. 2018 Mar;8(3):263.
doi: 10.1158/2159-8290.CD-RW2018-010. Epub 2018 Jan 19.

LXR Agonism Depletes MDSCs to Promote Antitumor Immunity

No authors listed
Comment

LXR Agonism Depletes MDSCs to Promote Antitumor Immunity

No authors listed. Cancer Discov. 2018 Mar.

Abstract

LXR activation reduces immunosuppressive MDSCs to activate antitumor cytotoxic T cells.

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  • LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer.
    Tavazoie MF, Pollack I, Tanqueco R, Ostendorf BN, Reis BS, Gonsalves FC, Kurth I, Andreu-Agullo C, Derbyshire ML, Posada J, Takeda S, Tafreshian KN, Rowinsky E, Szarek M, Waltzman RJ, Mcmillan EA, Zhao C, Mita M, Mita A, Chmielowski B, Postow MA, Ribas A, Mucida D, Tavazoie SF. Tavazoie MF, et al. Cell. 2018 Feb 8;172(4):825-840.e18. doi: 10.1016/j.cell.2017.12.026. Epub 2018 Jan 11. Cell. 2018. PMID: 29336888 Free PMC article.

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