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Review
. 2018 Jan 19;9(2):52.
doi: 10.1038/s41419-017-0084-6.

Molecular and physiological roles of the adaptor protein CARD9 in immunity

Xiaoming Zhong  1 , Bin Chen  2 , Liang Yang  3 , Zhiwen Yang  4
Affiliations
Review

Molecular and physiological roles of the adaptor protein CARD9 in immunity

Xiaoming Zhong et al. Cell Death Dis. .

Erratum in

Abstract

CARD9 is a caspase recruitment domain-containing signaling protein that plays a critical role in innate and adaptive immunity. It has been widely demonstrated that CARD9 adaptor allows pattern recognition receptors to induce NF-κB and MAPK activation, which initiates a "downstream" inflammation cytokine cascade and provides effective protection against microbial invasion, especially fungal infection. Here our aim is to update existing paradigms and summarize the most recent findings on the CARD9 signaling pathway, revealing significant mechanistic insights into the pathogenesis of CARD9 deficiency. We also discuss the effect of CARD9 genetic mutations on the in vivo immune response, and highlight clinical advances in non-infection inflammation.

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Conflict of interest statement

The authors declare that they have no financial interests.

Figures

Fig. 1
Fig. 1. CARD9-mediated signaling in response to microbial infection
a CLRs/NODs/TLRs-induced CARD9 activation. b CARD9 phosphorylation and ubiquitination
Fig. 2
Fig. 2
The structure of CARD9 and the genomic location of the CARD9 gene
Fig. 3
Fig. 3. Formation of the CARD9 signaling complex
a DsDNA/Rad50/CARD9 and TRAF6/BCL10/CARD9 signaling complexes. b CARD9-mediated inflammasomes
See this image and copyright information in PMC

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