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. 2018 Jan 19;8(1):1175.
doi: 10.1038/s41598-018-19243-y.

Association between modified CHA2DS2-VASc Score with Ankle-Brachial index < 0.9

Po-Chao Hsu  1   2 , Wen-Hsien Lee  1   2   3 , Hsiang-Chun Lee  1   2 , Wei-Chung Tsai  1   2 , Chun-Yuan Chu  1   2 , Ying-Chih Chen  1   3 , Chee-Siong Lee  1   2 , Tsung-Hsien Lin  1   2 , Wen-Chol Voon  1   2 , Sheng-Hsiung Sheu  1   2 , Ho-Ming Su  4   5   6
Affiliations

Association between modified CHA2DS2-VASc Score with Ankle-Brachial index < 0.9

Po-Chao Hsu et al. Sci Rep. .

Abstract

The ankle-brachial index (ABI) is a reliable diagnostic examination for peripheral arterial occlusive disease (PAOD). We previously reported CHADS2 score was significantly correlated with PAOD. However, the association between CHA2DS2-VASc score and ABI < 0.9 is not evaluated in the literature. The aim of the present study was to investigate whether CHA2DS2-VASc score has a strong association with PAOD. We enrolled 1482 patients in this study. PAOD was defined as ABI < 0.9 in either leg. Vascular disease in CHA2DS2-VASc score was modified as vascular disease except PAOD. Of the 1482 subjects, the prevalence of ABI < 0.9 was 5.6%. Multivariate analysis showed that the increased age, decreased estimated glomerular filtration rate and increased modified CHA2DS2-VASc score (OR, 1.764; p < 0.001) were independent associated with ABI < 0.9. In addition, the percentage of ABI < 0.9 in patients with modified CHA2DS2-VASc score of 0, 1, and <2 were 0%, 0.9%, and 0.7%, respectively (All < 1%). Our study demonstrated modified CHA2DS2-VASc score was significantly associated with ABI < 0.9. Calculation of modified CHA2DS2-VASc score might be useful in identifying patients with PAOD and in stratifying the risk of PAOD in non-AF patients.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
The percentage of ABI < 0.9 in patients with different modified CHA2DS2-VASc score (A) and in patients with modified CHA2DS2-VASc score <2 and ≥2 (B).
See this image and copyright information in PMC

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