Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986;21(1):51-7.
doi: 10.1007/BF00199377.

Suppression of murine NK activity induced by Corynebacterium parvum: further characterization and abrogation of suppressor cells

V K Milisauskas, G Cudkowicz, I Nakamura

Suppression of murine NK activity induced by Corynebacterium parvum: further characterization and abrogation of suppressor cells

V K Milisauskas et al. Cancer Immunol Immunother. 1986.

Abstract

Formalin-killed Corynebacterium parvum (CP), given at a dose of 0.4-0.7 mg/mouse IV or IP, induced suppressor cells for NK activity in B6C3F1 mice. The suppressor cells belong to at least two different populations, plastic adherent and nonadherent, and were not depleted by antibodies specific for Thy-1.2, Iak, or NK-1.2 surface markers. Administration of p-I:C, an interferon-inducer, to animals 18 h before the assay did not affect the suppressor activity. Hypotonic shock treatment of splenocytes abrogated the in vitro suppressive activity, and subsequent reconstitution of the shock-treated cells with RBC failed to restore the suppressive activity. SJL/J mice, which have low NK activity, exhibited suppressor activity comparable to B6C3F1 mice following CP treatment, whereas CP-treated BALB/c athymic and euthymic mice showed a lower ability to generate suppressors for NK as compared to B6C3F1 mice.

PubMed Disclaimer

References

    1. Blair PB, Staskawicz MO, Sam JS. Inhibitor cells in spleens of mice with low natural killer activity. J Natl Cancer Inst. 1983;71:571. - PubMed
    1. Brunda MJ, Taramelli D, Holden HT, Varesio L. Suppression of in vitro maintenance and interferon-mediated augmentation of natural killer cell activity by adherent peritoneal cells from normal mice. J Immunol. 1983;130:1974. - PubMed
    1. Burton RC, Winn HJ. Studies on natural killer (NK) cells. I. NK cell specific antibodies in CE anti-CBA serum. J Immunol. 1981;126:1985. - PubMed
    1. Clark EA, Windsor NT, Sturge JC, Stanton TH. Mutations that influence natural cell-mediated cytotoxicity in rodents. In: Herberman RB, editor. Natural cell-mediated immunity against tumors. New York: Academic Press; 1980. p. 417.
    1. Cudkowicz G, Hochman PS. Do natural killer cells cells engage in regulated reaction against self to ensure homeostasis? Immunol Rev. 1979;44:13. - PubMed

Publication types

LinkOut - more resources