Impact of delivered tidal volume on the occurrence of intraventricular haemorrhage in preterm infants during positive pressure ventilation in the delivery room

Abstract

Background and objectives: Delivery of inadvertent high tidal volume (V_T) during positive pressure ventilation (PPV) in the delivery room is common. High V_T delivery during PPV has been associated with haemodynamic brain injury in animal models. We examined if V_T delivery during PPV at birth is associated with brain injury in preterm infants <29 weeks' gestation.

Methods: A flow-sensor was placed between the mask and the ventilation device. V_T values were compared with recently described reference ranges for V_T in spontaneously breathing preterm infants at birth. Infants were divided into two groups: V_T<6 mL/kg or V_T>6 mL/kg (normal and high V_T, respectively). Brain injury (eg, intraventricular haemorrhage (IVH)) was assessed using routine ultrasound imaging within the first days after birth.

Results: A total of 165 preterm infants were included, 124 (75%) had high V_T and 41 (25%) normal V_T. The mean (SD) gestational age and birth weight in high and normal V_T group was similar, 26 (2) and 26 (1) weeks, 858 (251) g and 915 (250) g, respectively. IVH in the high V_T group was diagnosed in 63 (51%) infants compared with 5 (13%) infants in the normal V_T group (P=0.008).Severe IVH (grade III or IV) developed in 33/124 (27%) infants in the high V_T group and 2/41 (6%) in the normal V_T group (P=0.01).

Conclusions: High V_T delivery during mask PPV at birth was associated with brain injury. Strategies to limit V_T delivery during mask PPV should be used to prevent high V_T delivery.

Keywords: brain injury; delivery room; infants; neonatal resuscitation; newborn; respiratory functions tests.