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Review
. 2018 Jan-Feb;22(1):63-69.
doi: 10.1016/j.bjid.2018.01.001. Epub 2018 Jan 19.

Transmission of dengue virus from deceased donors to solid organ transplant recipients: case report and literature review

Fernando Rosso  1 , Juan C Pineda  2 , Ana M Sanz  3 , Jorge A Cedano  3 , Luis A Caicedo  4
Affiliations
Review

Transmission of dengue virus from deceased donors to solid organ transplant recipients: case report and literature review

Fernando Rosso et al. Braz J Infect Dis. 2018 Jan-Feb.

Abstract

Dengue fever is a vector-transmitted viral infection. Non-vectorial forms of transmission can occur through organ transplantation. We reviewed medical records of donors and recipients with suspected dengue in the first post-transplant week. We used serologic and molecular analysis to confirm the infection. Herein, we describe four cases of dengue virus transmission through solid organ transplantation. The recipients had positive serology and RT-PCR. Infection in donors was detected through serology. All cases presented with fever within the first week after transplantation. There were no fatal cases. After these cases, we implemented dengue screening with NS1 antigen detection in donors during dengue outbreaks, and no new cases were detected. In the literature review, additional cases had been published through August 2017. Transmission of Dengue virus can occur through organ donation. In endemic regions, it is important to suspect and screen for dengue in febrile and thrombocytopenic recipients in the postoperative period.

Keywords: Dengue virus; Screening; Solid organ transplantation; Transmission.

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Figures

Fig. 1
Fig. 1
Clinical course of dengue infection in recipients 1 and 2.
Fig. 2
Fig. 2
Clinical course of dengue infection in recipients 3 and 4.
See this image and copyright information in PMC

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References

    1. Wiwanitkit V. Non vector-borne transmission modes of dengue. J Infect Dev Ctries. 2010;4:051–54.
    1. Tan F.L.-S., Loh D.L.S.K., Prabhakaran K., Tambyah P.A., Yap H.-K. Dengue hemorrhagic fever after living donor renal transplantation. Nephrol Dial Transplant. 2005;20:1281. - PubMed
    1. Tangnararatchakit K., Tirapanich W., Tapaneya-Olarn W., et al. Severe nonfebrile dengue infection in an adolescent after postoperative kidney transplantation: a case report. Transplant Proc [Internet] 2012;44:303–306. - PubMed
    1. Gan V.C., Tan L.K., Lye D.C., et al. Diagnosing dengue at the point-of-care: utility of a rapid combined diagnostic kit in singapore. PLoS ONE. 2014;9:1–6. - PMC - PubMed
    1. World Health Organization (WHO) Regional Office for South-East Asia . 2nd ed. World Health Organization (WHO) Regional Office for South-East Asia, editor; 2016. Establishment of PCR laboratory in developing countries.