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Review
. 2018 Feb;41(2):233-240.
doi: 10.2337/dci17-0031.

Diabetes in Youth-Looking Backwards to Inform the Future: Kelly West Award Lecture 2017

Dana Dabelea  1
Affiliations
Review

Diabetes in Youth-Looking Backwards to Inform the Future: Kelly West Award Lecture 2017

Dana Dabelea. Diabetes Care. 2018 Feb.

Abstract

The Kelly West Award for Outstanding Achievement in Epidemiology is presented in honor of the memory of Kelly M. West, widely regarded as the "father of diabetes epidemiology." Harry Keen described West as characterized by "generosity of spirit, deeply human and humorous, deliberate of address, modest, conciliatory and untiringly persevering. Few people have done so much to change the landscape of diabetes" (1). The award and lecture recognize a leading epidemiologist in the field of diabetes. Dana Dabelea, MD, PhD, received this award at the American Diabetes Association's 77th Scientific Sessions, 9-13 June 2017, in San Diego, CA. She presented the Kelly West Award Lecture, "Diabetes in Youth-Looking Backwards to Inform the Future," on Sunday, 11 June 2017.

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Figures

Figure 1
Figure 1
The changing face of diabetes in youth. A: Increasing proportion of youth in diabetes clinics with type 2 diabetes between 1987 and 1996 (–8). B: Increasing prevalence of type 2 diabetes among Pima Indian girls and boys between two studies conducted between 1967 and 1976 and 1987 and 1996 (9).
Figure 2
Figure 2
A: Incidence rates (per 100,000 per year) for type 1 diabetes with onset <20 years of age in 2002–2003 in SEARCH. Based on 1,905 youth with type 1 diabetes in 10 million person-years at risk. B: Incidence rates (per 100,000 per year) for type 2 diabetes with onset <20 years of age in 2002–2003 in SEARCH (11). Based on 530 youth with type 2 diabetes in 10 million person-years at risk. For children aged 0 to 4 years and 5 to 9 years, virtually all diabetes was type 1, regardless of race/ethnicity, so data are not shown.
Figure 3
Figure 3
A: Age-, sex-, and race/ethnicity-adjusted type 1 diabetes incidence rates (per 100,000 per year) by race/ethnicity and year of diagnosis (12). Over all race/ethnicity groups, type 1 diabetes rates increased 1.8% per year (dashed line). B: Age-, sex-, and race/ethnicity-adjusted type 2 diabetes incidence rates (per 100,000 per year) by race/ethnicity and year of diagnosis. Over all race/ethnicity groups, type 2 diabetes rates increased 4.8% per year (dashed line). Adapted with permission from Mayer-Davis et al. (12).
Figure 4
Figure 4
Temporal trends in type 1 diabetes by geographic location and incidence year (2). The dashed line is contemporary U.S. data from SEARCH (12).
Figure 5
Figure 5
Temporal trends in incidence rates for type 2 diabetes by geographic area and year of diagnosis. SEARCH data are shown in solid lines (2).
Figure 6
Figure 6
Prevalence of diabetes complications and comorbidities by type of outcome and race/ethnicity, adjusted to 21 years of age (21). Other, NHB, HISP, API, and AIAN combined.
Figure 7
Figure 7
The vicious cycle of transgenerational obesity and diabetes, including potential times when the cycle might be broken through effective interventions.
See this image and copyright information in PMC

References

    1. Gale EAM. Kelly West (1925-1980) [Internet], 13 August 2014. Available from https://doi.org/1014496/dia1104696428.8. Accessed 4 September 2017
    1. Dabelea D, Hamman RF, Knowler WC. Diabetes in youth. In Diabetes in America. 3rd. ed Cowie CC, Casagrande SS, Menke A, et al., Eds. Bethesda, MD, National Institutes of Health, 2017, p. 15.1–15.54
    1. Gale EA. The rise of childhood type 1 diabetes in the 20th century. Diabetes 2002;51:3353–3361 - PubMed
    1. Patterson C, Guariguata L, Dahlquist G, Soltész G, Ogle G, Silink M. Diabetes in the young - a global view and worldwide estimates of numbers of children with type 1 diabetes. Diabetes Res Clin Pract 2014;103:161–175 - PubMed
    1. Kostraba JN, Gay EC, Cai Y, et al. Incidence of insulin-dependent diabetes mellitus in Colorado. Epidemiology 1992;3:232–238 - PubMed