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Review
. 2018 Jan 7;24(1):15-22.
doi: 10.3748/wjg.v24.i1.15.

Updated review on immune factors in pathogenesis of Crohn's disease

Na Li  1 , Rui-Hua Shi  1
Affiliations
Review

Updated review on immune factors in pathogenesis of Crohn's disease

Na Li et al. World J Gastroenterol. .

Abstract

Although the incidence of Crohn's disease (CD) in China is not as high as that in European and American countries, there has been a clear increasing trend in recent years. Little is known about its pathogenesis, cause of deferment, and the range of complications associated with the disease. Local and international scholars have presented many hypotheses about CD pathogenesis based on experimental and clinical studies, including genetic susceptibility, immune function defects, intestinal microflora disorders, delayed hypersensitivity, and food antigen stimulation. However, the specific mechanism leading to this immune imbalance, which causes persistent intestinal mucosal damage, and the source of the inflammatory cascade reaction are still unclear. So far, the results of research studies differ locally and internationally. This paper presents the most current research on immune factors in the pathogenesis of CD.

Keywords: Crohn’s disease; Cytokines; Immune; Immunotherapy; Intestinal inflammation; Lymphocytes; Pathogenesis; T lymphocytes.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflicts of interest to this work.

Figures

Figure 1
Figure 1
The main immune process of Crohn's disease.
Figure 2
Figure 2
The main immune mechanisms of Crohn's disease.
See this image and copyright information in PMC

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