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Editorial
. 2017 Dec 18:4:97.
doi: 10.21037/sci.2017.12.01. eCollection 2017.

Integrin α7: a major driver and therapeutic target for glioblastoma malignancy

Andreia M Nunes  1 , Pamela Barraza-Flores  1 , Christina R Smith  1 , Dean J Burkin  1
Affiliations
Editorial

Integrin α7: a major driver and therapeutic target for glioblastoma malignancy

Andreia M Nunes et al. Stem Cell Investig. .
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare

Figures

Figure 1
Figure 1
Integrin α7 signaling in glioblastoma cells. Model of integrin α7 signaling pathway associated with glioblastoma stem cell proliferation and invasion. Glioblastoma stem cells express higher levels of integrin α7 as well as phosphorylated Akt, FAK, and Src compared to differentiating glioblastoma cells, resulting in militant tumorigenic properties.
Figure 2
Figure 2
Integrin α7 expression in various stem cells. Integrin α7 expression levels are shared at stem-like stages and diverge as cells drive more toward differentiation. (A) Glioblastoma stem cells express high levels of integrin α7 followed by down regulation as they progress toward malignancy; (B) proposed (dotted line) expression level of Integrin α7 in melanoma luminal or basal cells during differentiation; (C) muscle cells maintain elevated levels of integrin α7 from stem cells to myofibers.
See this image and copyright information in PMC

Comment on

  • Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma.
    Haas TL, Sciuto MR, Brunetto L, Valvo C, Signore M, Fiori ME, di Martino S, Giannetti S, Morgante L, Boe A, Patrizii M, Warnken U, Schnölzer M, Ciolfi A, Di Stefano C, Biffoni M, Ricci-Vitiani L, Pallini R, De Maria R. Haas TL, et al. Cell Stem Cell. 2017 Jul 6;21(1):35-50.e9. doi: 10.1016/j.stem.2017.04.009. Epub 2017 Jun 9. Cell Stem Cell. 2017. PMID: 28602620

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