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Comparative Study
. 2018 Jun 1;197(11):1496-1499.
doi: 10.1164/rccm.201712-2405LE.

Disproportionate Right Ventricular Dysfunction and Poor Survival in Group 3 Pulmonary Hypertension

Kurt W Prins  1 , Lauren Rose  1 , Stephen L Archer  2 , Marc Pritzker  1 , E Kenneth Weir  1 , Felipe Kazmirczak  1 , Jeffrey R Misialek  1 , Thenappan Thenappan  1
Affiliations
Comparative Study

Disproportionate Right Ventricular Dysfunction and Poor Survival in Group 3 Pulmonary Hypertension

Kurt W Prins et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Worse right ventricular (RV) function and increased mortality in group 3 pulmonary hypertension (PH). (A) Top: reduced RV fractional area change (RVFAC) in group 3 PH compared with group 1 PH (28 ± 10% vs. 33 ± 11%, P = 0.006). Bottom: plot of RVFAC versus mean pulmonary artery pressure (mPAP) in group 1 and group 3 patients. Group 3 patients had worse RV function at all mPAPs, as demonstrated by a significantly different y intercept (group 3: 44.2 ± 4.3, group 1: 47.9 ± 4.2, P < 0.0001). However, there was an equivalent response to increasing afterload, as shown by the similar slope of best-fit regression lines (group 3: −0.38 ± 0.10, group 1: −0.33 ± 0.09, P = 0.70). *P < 0.05 (t test). (B) Survival analysis shows significantly worse survival for group 3 PH in the total cohort (top) and incident cohort (bottom). CI = confidence interval; WHO = World Health Organization.
See this image and copyright information in PMC

References

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