Twin studies for the prognosis, prevention and treatment of musculoskeletal conditions

Lucas Calais-Ferreira¹, Vinicius C Oliveira², Jeffrey M Craig³, Louisa B Flander⁴, John L Hopper⁴, Luci F Teixeira-Salmela⁵, Paulo H Ferreira⁶

Affiliations

¹ The University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, Victoria, Australia. Electronic address: lucas.cf@unimelb.edu.au.
² Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Diamantina, MG, Brazil.
³ Deakin University, School of Medicine, Centre for Molecular and Medical Research, Geelong, Victoria, Australia; Royal Children's Hospital, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; The University of Melbourne, Department of Paediatrics, Melbourne, Victoria, Australia.
⁴ The University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, Victoria, Australia.
⁵ Universidade Federal de Minas Gerais (UFMG), Departamento de Fisioterapia, Belo Horizonte, MG, Brazil.
⁶ The University of Sydney, Faculty of Health Sciences, Musculoskeletal Health Research Group, Sydney, New South Wales, Australia.

PMID: 29361503
PMCID: PMC5993967
DOI: 10.1016/j.bjpt.2017.12.004

Review

Twin studies for the prognosis, prevention and treatment of musculoskeletal conditions

Lucas Calais-Ferreira et al. Braz J Phys Ther. 2018 May-Jun.

. 2018 May-Jun;22(3):184-189.

doi: 10.1016/j.bjpt.2017.12.004. Epub 2017 Dec 27.

Authors

Lucas Calais-Ferreira¹, Vinicius C Oliveira², Jeffrey M Craig³, Louisa B Flander⁴, John L Hopper⁴, Luci F Teixeira-Salmela⁵, Paulo H Ferreira⁶

Affiliations

¹ The University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, Victoria, Australia. Electronic address: lucas.cf@unimelb.edu.au.
² Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Diamantina, MG, Brazil.
³ Deakin University, School of Medicine, Centre for Molecular and Medical Research, Geelong, Victoria, Australia; Royal Children's Hospital, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; The University of Melbourne, Department of Paediatrics, Melbourne, Victoria, Australia.
⁴ The University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, Victoria, Australia.
⁵ Universidade Federal de Minas Gerais (UFMG), Departamento de Fisioterapia, Belo Horizonte, MG, Brazil.
⁶ The University of Sydney, Faculty of Health Sciences, Musculoskeletal Health Research Group, Sydney, New South Wales, Australia.

PMID: 29361503
PMCID: PMC5993967
DOI: 10.1016/j.bjpt.2017.12.004

Abstract

Background: Musculoskeletal conditions are highly prevalent in our ageing society and are therefore incurring substantial increases in population levels of years lived with disability (YLD). An evidence-based approach to the prognosis, prevention, and treatment of those disorders can allow an overall improvement in the quality of life of patients, while also softening the burden on national health care systems.

Methods: In this Masterclass article, we provide an overview of the most relevant twin study designs, their advantages, limitations and major contributions to the investigation of traits related to the domain of musculoskeletal physical therapy.

Conclusions: Twin studies can be an important scientific tool to address issues related to musculoskeletal conditions. They allow researchers to understand how genes and environment combine to influence human health and disease. Twin registries and international collaboration through existing networks can provide resources for achieving large sample sizes and access to expertise in study design and analysis of twin data.

Keywords: Brazilian twin registry; International collaboration; Musculoskeletal research; Twin studies.

PubMed Disclaimer

Cited by

Is occupational or leisure physical activity associated with low back pain? Insights from a cross-sectional study of 1059 participants.
B Amorim A, Simic M, Pappas E, Zadro JR, Carrillo E, Ordoñana JR, Ferreira PH. B Amorim A, et al. Braz J Phys Ther. 2019 May-Jun;23(3):257-265. doi: 10.1016/j.bjpt.2018.06.004. Epub 2018 Jun 28. Braz J Phys Ther. 2019. PMID: 31130170 Free PMC article.
Comparison of the Differences in State-Trait Anxiety Inventory Scores and Insomnia Histories between Monozygotic and Dizygotic Twins: A Cross-Sectional Study Using KoGES HTS Data.
Kim SY, Yoo DM, Kwon MJ, Kim JH, Kim JH, Bang WJ, Choi HG. Kim SY, et al. J Clin Med. 2022 Jul 11;11(14):4011. doi: 10.3390/jcm11144011. J Clin Med. 2022. PMID: 35887774 Free PMC article.
Contributions of birthweight, annualised weight gain and BMI to back pain in adults: a population-based co-twin control study of 2754 Australian twins.
Leite HR, Dario AB, Harmer AR, Oliveira VC, Ferreira ML, Calais-Ferreira L, Ferreira PH. Leite HR, et al. Eur Spine J. 2019 Feb;28(2):224-233. doi: 10.1007/s00586-018-5850-3. Epub 2018 Dec 6. Eur Spine J. 2019. PMID: 30523461

References

1. Anthony W., Bruce P. Burden of major musculoskeletal conditions. Bull World Health Organ. 2003;9:646–656. - PMC - PubMed
1. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;(10053):1545. - PMC - PubMed
1. Yelin E., Weinstein S., King T. The burden of musculoskeletal diseases in the United States. Semin Arthritis Rheum. 2016;(3):259. - PubMed
1. Galton F. The history of twins, as a criterion of the relative powers of nature and nurture. J Royal Anthropol Inst. 1876:391. - PubMed
1. Pocock N.A., Eisman J.A., Yeates M.G., Sambrook P.N., Eberl S. Genetic determinants of bone mass in adults: a twin study. Aust N Z J Med. 1987;17(suppl 1) - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Twin studies for the prognosis, prevention and treatment of musculoskeletal conditions

Affiliations

Twin studies for the prognosis, prevention and treatment of musculoskeletal conditions

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources