Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan 21;9(1):12.
doi: 10.3390/jfb9010012.

Route and Type of Formulation Administered Influences the Absorption and Disposition of Vitamin B12 Levels in Serum

Luis Vitetta  1   2 , Joyce Zhou  3 , Rachel Manuel  4 , Serena Dal Forno  5 , Sean Hall  6 , David Rutolo  7
Affiliations

Route and Type of Formulation Administered Influences the Absorption and Disposition of Vitamin B12 Levels in Serum

Luis Vitetta et al. J Funct Biomater. .

Abstract

The administration of biological compounds that optimize health benefits is an ever-evolving therapeutic goal. Pharmaceutical and other adjunctive biological compounds have been administered via many different routes in order to produce a systemic pharmacological effect. The article summarizes the findings from an Australian comparative study in adults administered vitamin B12 through different oral delivery platforms. A total of 16 subjects (9 males, 7 females) voluntarily partook in a comparative clinical study of five different vitamin B12 formulations across a six-month period, completing 474 person-hours of cumulative contribution, that was equivalent to an n = 60 participation. A nanoparticle delivered vitamin B12 through a NanoCelle platform was observed to be significantly (p < 0.05) better absorbed than all other dose equivalent platforms (i.e., tablets, emulsions, or liposomes) from baseline to 1, 3, and 6 h of the study period. The nanoparticle platform delivered vitamin B12 demonstrated an enhanced and significant absorption profile as exemplified by rapid systemic detection (i.e., 1 h from baseline) when administered to the oro-buccal mucosa with no reports of any adverse events of toxicity. The nanoparticle formulation of methylcobalamin (1000 µg/dose in 0.3 mL volume) showed bioequivalence only with a chewable-dissolvable tablet that administered a five times higher dose of methylcobalamin (5000 µg) per tablet. This study has demonstrated that an active metabolite embedded in a functional biomaterial (NanoCelle) may constitute a drug delivery method that can better access the circulatory system.

Keywords: NanoCelle; cyanocobalamin; emulsion; liposome; methylcobalamin; nanoparticles; tablets; vitamin B12.

PubMed Disclaimer

Conflict of interest statement

L.V., J.Z., R.M., S.D.F., S.H., and D.R. participate in Medlab Clinical’s nanoparticle delivery technology research. The authors have no further conflicts of interest relevant to the content of this manuscript.

Figures

Figure 1
Figure 1
NanoCelle particle size by distribution.
Figure 2
Figure 2
NanoCelle particle size distribution by intensity.
Figure 3
Figure 3
Serum B12 disposition from baseline to 6 h for the five formulations tested.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Zhang C., Rodriguez E., Bi C., Zheng X., Suresh D., Suh K., Li Z., Elsebaei F., Hage D.S. High performance affinity chromatography and related separation methods for the analysis of biological and pharmaceutical agents. Analyst. 2018;143:374–391. doi: 10.1039/C7AN01469D. - DOI - PMC - PubMed
    1. Mopuri R., Islam M.S. Medicinal plants and phytochemicals with anti-obesogenic potentials: A review. Biomed. Pharmacother. 2017;89:1442–1452. doi: 10.1016/j.biopha.2017.02.108. - DOI - PubMed
    1. Sun N.N., Wu T.Y., Chau C.F. Natural dietary and herbal products in anti-obesity treatment. Molecules. 2016;21 doi: 10.3390/molecules21101351. - DOI - PMC - PubMed
    1. Jin J.F., Zhu L.L., Chen M., Xu H.M., Wang H.F., Feng X.Q., Zhu X.P., Zhou Q. The optimal choice of medication administration route regarding intravenous, intramuscular, and subcutaneous injection. Patient Preference Adherence. 2015;9:923–942. - PMC - PubMed
    1. Kwan K.C. Oral bioavailability and first-pass effects. Drug Metab. Dispos. 1997;25:1329–1336. - PubMed

LinkOut - more resources