Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Apr;144(4):717-723.
doi: 10.1007/s00432-018-2581-0. Epub 2018 Jan 23.

Clinical characteristics and outcomes of cancer patients requiring intensive care unit admission: a prospective study

Frank Daniel Martos-Benítez  1 , Andrés Soto-García  2 , Anarelys Gutiérrez-Noyola  2
Affiliations

Clinical characteristics and outcomes of cancer patients requiring intensive care unit admission: a prospective study

Frank Daniel Martos-Benítez et al. J Cancer Res Clin Oncol. 2018 Apr.

Abstract

Purpose: The study was aimed to describe the characteristics of cancer patients admitted to the oncological ICU and to identify clinical features associated with outcomes.

Methods: This is a prospective study (January 2014 to December 2015) of 522 cancer patients consecutively admitted to the oncological ICU. Patients with a length of oncological ICU stay ≤ 1 day were excluded. Demographic and clinical variables were obtained at oncological ICU admission. The primary outcome of interest was hospital mortality. Logistic regression analysis was performed to identify independent risk factors for hospital mortality.

Results: The study cohort consisted of 492 (94.3%) patients with solid tumours and 30 patients (5.7%) with haematological malignancies. Advanced cancer was observed in 53.3%. Unplanned admission accounted for 25.3%. Hospital mortality rate was 13.0% (n = 68), and it was higher for patients with unplanned admission than those for electively admitted patients (35.6% vs. 5.4; p < 0.0001). Stage IV of cancer (OR 5.28; 95% CI 2.71-10.28; p < 0.0001), patients from the emergency department (OR 3.33; 95% CI 1.68-6.61; p = 0.001), unplanned admission (OR 7.99; 95% CI 4.45-14.33; p < 0.0001), non-malignancy-related admission (OR 5.80; 95% CI 3.26-10.32; p < 0.0001), sepsis (OR 4.81; 95% CI 2.28-10.16; p < 0.0001), chemotherapy-induced adverse event (OR 5.64; 95% CI 2.33-13.66; p < 0.0001), and invasive mechanical ventilation (OR 18.70; 95% CI 9.93-35.21; p < 0.0001) were independently associated with increased hospital mortality in multivariate logistic regression analysis.

Conclusions: ICU admission of cancer patients should be based on potential chance of recovering from the acute problem. Clinical predictor for mortality could support this purpose (UIN: researchregistry3484).

Keywords: APACHE; Cancer; Critically ill patient; Mechanical ventilation; Mortality; Outcome; Sepsis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Flow diagram of study participants. ICU intensive care unit
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Almeida IC, Soares M, Bozza FA, Shinotsuka CR, Bujokas R, Souza-Dantaset VC et al (2014) The impact of acute brain dysfunction in the outcomes of mechanically ventilated cancer patients. PLoS One 9:e85332 - PMC - PubMed
    1. Anisoglou S, Asteriou C, Barbetakis N, Kakolyris S, Anastasiadou G, Pnevmatikos I (2013) Outcome of lung cancer patients admitted to the intensive care unit with acute respiratory failure. Hippokratia 17:60–63 - PMC - PubMed
    1. Aygencel G, Turkoglu M, Turkoz G, Benekli M (2014) Prognostic factors in critically ill cancer patients admitted to the intensive care unit. J Crit Care 29:618–626 - PubMed
    1. Azevedo LC, Caruso P, Silva UV, Torelly AP, Silva E, Rezende E et al (2014) Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study. Chest 146:257–266 - PubMed
    1. Blot SI, Poelaert J, Kollef M (2014) How to avoid microaspiration? A key element for the prevention of ventilator-associated pneumonia in intubated ICU patients. BMC Infect Dis 14:119 - PMC - PubMed

LinkOut - more resources