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Review
. 2017 Dec;19(3):87-97.
doi: 10.4321/S1575-06202017000300004.

Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection

A Flores-Chávez  1 , J A Carrion  2 , X Forns  3 , M Ramos-Casals  4
Affiliations
Review

Extrahepatic manifestations associated with Chronic Hepatitis C Virus Infection

A Flores-Chávez et al. Rev Esp Sanid Penit. 2017 Dec.

Abstract
in English, Spanish

Chronic hepatitis C virus (HCV) infection has been associated with both organ-specific and systemic autoimmune diseases, with cryoglobulinemia being the most frequent associated disease. Experimental, virologic, and clinical evidence have demon-strated a close association between HCV infection and some systemic autoimmune diseases, especially Sjögren's syndrome, but also rheumatoid arthritis and lupus. A higher prevalence of hematological processes has also been described in patients with HCV infection, including cytopenias and lymphoproliferative disorders (B-cell lymphoma). In addition, patients with chronic HCV infection have a higher frequency of other extrahepatic manifestations including endocrine, metabolic and cardiovascular disorders that may worse the prognosis of patients, along with neuropsychiatric manifestations and general symptoms that have a significant influence on the quality of life of the patient. Direct-acting antiviral therapies (DAAs) that have recently begun to be used are providing the opportunity to effectively cure chronic HCV infection and reduce the burden of both hepatic and extrahepatic complications.

La infección crónica por el virus de la hepatitis C (VHC) se ha asociado tanto a enfermedades autoinmunes específicas de órganos como a enfermedades autoinmunes sistémicas, siendo la más frecuente la crioglobulinemia. Las evidencias experimentales, virológicas y clínicas han demostrado una estrecha asociación entre la infección por el VHC con algunas enfermedades autoinmunes sistémicas, especialmente el síndrome de Sjögren, junto con la artritis reumatoide y el lupus. Se ha descrito una mayor prevalencia de procesos hematológicos en pacientes con infección por VHC, incluyendo citopenias y trastornos linfoproliferativos como el linfoma B. Además, los pacientes con infección crónica por el VHC presentan una mayor frecuencia de otras manifestaciones extrahepáticas que incluyen alteraciones endocrinas, metabólicas y cardiovasculares que pueden afectar seriamente el pronóstico de los pacientes, junto con manifestaciones neuropsiquiátricas y de afectación del estado general que influyen notablemente en la calidad de vida del paciente. Las terapias antivirales de acción directa (DAA) que han empezado a utilizarse recientemente están proporcionando la oportunidad de curar eficazmente la infección crónica por VHC y reducir la carga causada por las complicaciones hepáticas y extrahepáticas.

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Figures

Figure 1
Figure 1. Classification of extrahepatic manifestations associated with chronic HCV infection.
See this image and copyright information in PMC

References

    1. Ramos-Casals M, Font J, Ingelmo M. Prevalence and clinical significance of hepatitis C virus infection in systemic autoimmune diseases. Med Clin (Barc) 2001 May 19;116(18):701–709. - PubMed
    1. Ramos-Casals M, Font J. Extrahepatic manifestations in patients with chronic hepatitis C virus infection. Curr Opin Rheumatol. 2005 Jul;17(4):447–455. - PubMed
    1. Juan Jd, de la Hoya PS, Marco A, Antón JJ, Faraco I, Yllobre C, et al. Multicenter study on the discontinuation and efficacy of chronic hepatitis C treatment in the Spanish penitentiary population (EPIBAND study) Eur J Gastroenterol Hepatol. 2014 Oct;26(10):1083–1089. - PubMed
    1. Marco A, Gallego C, Caylà JA. Incidence of hepatitis C infection among prisoners by routine laboratory values during a 20-year period. PLoS One. 2014 Feb 28;9(2):e90560. - PMC - PubMed
    1. Marco A, Esteban JI, Solé C, da Silva A, Ortiz J, Roget M, et al. Hepatitis C virus reinfection among prisoners with sustained virological response after treatment for chronic hepatitis C. J Hepatol. 2013 Jul;59(1):45–51. - PubMed

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