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Multicenter Study
. 2017 Oct-Dec;34(4):677-681.
doi: 10.17843/rpmesp.2017.344.2830.

[Concentration of Malondialdehyde in Subjects Living at High Altitudes: Exploratory Study]

[Article in Spanish]
Ingrid Gaby Melgarejo Pomar  1   2 , Elfride Balanza Erquicia  1   2 , Lizeth Torrez Colmena  1   2 , Sergio Quisberth Barrera  3 , Pilar Leina Suzaño Vargas  3
Affiliations
Free article
Multicenter Study

[Concentration of Malondialdehyde in Subjects Living at High Altitudes: Exploratory Study]

[Article in Spanish]
Ingrid Gaby Melgarejo Pomar et al. Rev Peru Med Exp Salud Publica. 2017 Oct-Dec.
Free article

Abstract
in English, Spanish

The objective of this study was to determine the levels of malondialdehyde (MDA), an oxidative stress biomarker, in individuals living at high altitudes (3500-4200 m). This exploratory study evaluated 91 subjects from La Paz and El Alto using a questionnaire and clinical examination. MDA levels were measured using a colorimetric technique. Measures of central tendency, dispersion, and percentages were used to describe data, and the Mann-Whitney test and Kruskal-Wallis test were used to assess differences between the sexes, age groups, and altitudes. The median concentration of MDA was 4.1 μmol/L (RIC 2.4-5.4) and the highest concentration of MDA was found in individuals older than 40 years. The average MDA levels were higher than those found at sea level, a result we believe is due to the effect of hypoxia. However, there were no differences in the MDA levels between the sexes or age groups.

El objetivo fue investigar el comportamiento del malondialdehido (MDA), biomarcador de estrés oxidativo, a grandes altitudes (3500-4200 m de altitud). Se realizó un estudio exploratorio en 91 sujetos de las ciudades de La Paz y El Alto seleccionados a través de una encuesta y examen clínico; la determinación de MDA se realizó con una técnica colorimétrica. Las medidas de tendencia central, dispersión y porcentajes se usaron para la descripción de datos, la prueba de Mann Whitney y Kruscal Wallis para explorar diferencias entre varones y mujeres, grupo etario y altitud. La mediana de concentración de MDA fue de 4,1 µmol/L (RIC 2,4-5,4), la mayor concentración se encontró en mayores de 40 años. El valor de la media encontrada es mayor que los referidos para el nivel del mar y supone la influencia de la hipoxia sobre los valores del MDA, sin embargo, no se encontraron diferencias entre sexo y grupos etarios.

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