Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan 10;1(1):CD006366.
doi: 10.1002/14651858.CD006366.pub4.

Surgery for postvitrectomy cataract

Diana V Do  1 , Stephen Gichuhi, Satyanarayana S Vedula, Barbara S Hawkins
Affiliations

Surgery for postvitrectomy cataract

Diana V Do et al. Cochrane Database Syst Rev. .

Abstract

Background: Cataract formation or acceleration can occur after intraocular surgery, especially following vitrectomy, a surgical technique for removing the vitreous that is used in the treatment of many disorders that affect the posterior segment of the eye. The underlying problem that led to vitrectomy may limit the benefit from removal of the cataractous lens.

Objectives: To evaluate the effectiveness and safety of surgery versus no surgery for postvitrectomy cataract with respect to visual acuity, quality of life, and other outcomes.

Search methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2017, Issue 5), MEDLINE Ovid (1946 to 17 May 2017), Embase.com (1947 to 17 May 2017), PubMed (1946 to 17 May 2017), Latin American and Caribbean Health Sciences Literature database (LILACS) (January 1982 to 17 May 2017), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com); last searched May 2013, ClinicalTrials.gov (www.clinicaltrials.gov); searched 17 May 2017, and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en); searched 17 May 2017. We did not use any date or language restrictions in the electronic searches for trials.

Selection criteria: We planned to include randomized controlled trials (RCTs) and quasi-RCTs that had compared surgery versus no surgery to remove the lens from eyes of adults in which cataracts had developed following vitrectomy.

Data collection and analysis: Two review authors independently screened the search results according to the standard methodological procedures expected by Cochrane.

Main results: We found no RCTs or quasi-RCTs that had compared surgery versus no surgery to remove the lens from eyes of adults in which cataracts had developed following vitrectomy.

Authors' conclusions: There is no evidence from RCTs or quasi-RCTs on which to base clinical recommendations for surgery for postvitrectomy cataract. There is a clear need for RCTs to address this evidence gap. Such trials should stratify participants by their age, the retinal disorder leading to vitrectomy, and the status of the underlying disease process in the contralateral eye. Outcomes assessed in such trials may include changes (both gains and losses) of visual acuity, quality of life, and adverse events such as posterior capsular rupture and retinal detachment. Both short-term (six-month) and long-term (one- or two-year) outcomes should be examined.

PubMed Disclaimer

Conflict of interest statement

Diana V Do: None known. Stephen Gichuhi: None known. Satyanarayana S Vedula: None known. Barbara S Hawkins: None known.

Figures

1
1
Study flow diagram.
See this image and copyright information in PMC

Update of

References

References to studies excluded from this review

Ahmadieh 2005 {published data only}
    1. Ahmadieh H, Moradian S, Faghihi H, Parvaresh MM, Ghanbari H, Mehryar M, et al. Anatomic and visual outcomes of scleral buckling versus primary vitrectomy in pseudophakic and aphakic retinal detachment: six‐month follow‐up results of a single operation — report no. 1. Ophthalmology 2005;112(8):1421‐9. - PubMed
Asaria 2001 {published data only}
    1. Asaria RH, Kon CH, Bunce C, Charteris DG, Wong D, Khaw PT, et al. Adjuvant 5‐fluorouracil and heparin prevents proliferative vitreoretinopathy: results from a randomized, double‐blind, controlled clinical trial. Ophthalmology 2001;108(7):1179‐83. - PubMed
Batman 1999 {published data only}
    1. Batman C, Cekic O. Vitrectomy with silicone oil or long‐acting gas in eyes with giant retinal tears: long‐term follow‐up of a randomized clinical trial. Retina 1999;19(3):188‐92. - PubMed
Blankenship 1980 {published data only}
    1. Blankenship GW. The lens influence on diabetic vitrectomy results. Report of a prospective randomized study. Archives of Ophthalmology 1980;98(12):2196‐8. - PubMed
DRVS 1985 {published data only}
    1. The Diabetic Retinopathy Vitrectomy Study Research Group. Early vitrectomy for severe proliferative diabetic retinopathy in eyes with useful vision. Results of a randomized trial — Diabetic Retinopathy Vitrectomy Study Report 3. The Diabetic Retinopathy Vitrectomy Study Research Group. Ophthalmology 1988;95(10):1307‐20. - PubMed
    1. The Diabetic Retinopathy Vitrectomy Study Research Group. Early vitrectomy for severe vitreous hemorrhage in diabetic retinopathy. Four‐year results of a randomized trial: Diabetic Retinopathy Vitrectomy Study Report 5. Archives of Ophthalmology 1990;108(7):958‐64. - PubMed
    1. The Diabetic Retinopathy Vitrectomy Study Research Group. Early vitrectomy for severe vitreous hemorrhage in diabetic retinopathy. Two‐year results of a randomized trial. Diabetic Retinopathy Vitrectomy Study Report 2. The Diabetic Retinopathy Vitrectomy Study Research Group. Archives of Ophthalmology 1985;103(11):1644‐52. - PubMed
Ehud 1988 {published data only}
    1. Ehud A, Varda C, Joseph M, Giora T. Management of complicated retinal detachment by vitrectomy and silicone oil injection. Metabolic, Pediatric, and Systemic Ophthalmology 1988;11(1‐2):63‐6. - PubMed
Ezra 2004 {published data only}
    1. Ezra E, Gregor ZJ. Surgery for idiopathic full‐thickness macular hole: two‐year results of a randomized clinical trial comparing natural history, vitrectomy, and vitrectomy plus autologous serum: Morfields Macular Hole Study Group Report no. 1. Archives of Ophthalmology 2004;122(2):224‐36. - PubMed
Freeman 1997 {published data only}
    1. Freeman WR, Azen SP, Kim JW, el‐Haig W, Mishell DR 3rd, Bailey I. Vitrectomy for the treatment of full‐thickness stage 3 or 4 macular holes. Results of a multicentered randomized clinical trial. The Vitrectomy for Treatment of Macular Hole Study Group. Archives of Ophthalmology 1997;115(1):11‐21. - PubMed
Haimann 1984 {published data only}
    1. Haimann MH, Abrams GW. Prevention of lens opacification during diabetic vitrectomy. Ophthalmology 1984;91(2):116‐21. - PubMed
Silicone Study 1992 {published data only}
    1. Vitrectomy with silicone oil or perfluoropropane gas in eyes with severe proliferative vitreoretinopathy: results of a randomized clinical trial. Silicone Study Report 2. Archives of Ophthalmology 1992;110(6):780‐92. - PubMed
    1. Vitrectomy with silicone oil or sulfur hexafluoride gas in eyes with severe proliferative vitreoretinopathy: results of a randomized clinical trial. Silicone Study Report 1. Archives of Ophthalmology 1992;110(6):770‐9. - PubMed
    1. Abrams GW, Azen SP, McCuen BW 2nd, Flynn HW Jr, Lai MY, Ryan SJ. Vitrectomy with silicone oil or long‐acting gas in eyes with severe proliferative vitreoretinopathy: results of additional and long‐term follow‐up. Silicone Study Report 11. Archives of Ophthalmology 1997;115(3):335‐44. - PubMed

Additional references

Ahfat 2003
    1. Ahfat FG, Yuen CH, Groenewald CP. Phacoemulsification and intraocular lens implantation following pars plana vitrectomy: a prospective study. Eye 2003;17(1):16‐20. - PubMed
Barañano 2007
    1. Barañano AE, Wu J, Mazhar K, Azen SP, Varma R, Los Angeles Latino Eye Study Group. Visual acuity outcomes after cataract extraction in adult Latinos. The Los Angeles Latino Eye Study. Ophthalmology 2008;115(5):815‐21. - PMC - PubMed
Benson 1988
    1. Benson WE. Vitrectomy in clinical ophthalmology. In: Duane TD editor(s). Duane's Clinical Ophthalmology. Vol. 5, Philadelphia: Lippincott, 1988:15‐7.
Bird 1995
    1. Bird AC, Bressler NM, Bressler SB, Chisholm IH, Coscas G, Davis MD, et al. An international classification and grading system for age‐related maculopathy and age‐related macular degeneration. The International ARM Epidemiological Study Group. Survey of Ophthalmology 1995;39(5):367‐74. - PubMed
Biro 2002
    1. Biro Z, Kovacs B. Results of cataract surgery in previously vitrectomized eyes. Journal of Cataract and Refractive Surgery 2002;28(6):1003‐6. - PubMed
Cheng 2001
    1. Cheng L, Azen SP, El‐Bradey MH, Scholz BM, Chaidhawangul S, Toyoguchi M, et al. Duration of vitrectomy and postoperative cataract in the Vitrectomy for Macular Hole Study. American Journal of Ophthalmology 2001;132(6):881‐7. - PubMed
Cherfan 1991
    1. Cherfan GM, Michels RG, Bustros S, Enger C, Glaser BM. Nuclear sclerotic cataract after vitrectomy for idiopathic epiretinal membranes causing macular pucker. American Journal of Ophthalmology 1991;111(4):434‐8. - PubMed
de Bustros 1988
    1. Bustros S, Thompson JT, Michels RG, Enger C, Rice TA, Glaser BM. Nuclear sclerosis after vitrectomy for idiopathic epiretinal membrane. American Journal of Ophthalmology 1988;105(2):160‐4. - PubMed
ETDRS 1991
    1. Fundus photographic risk factors for progression of diabetic retinopathy. ETDRS report number 12. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology 1991;98(Suppl 5):823‐33. - PubMed
GRADEpro 2014 [Computer program]
    1. GRADE Working Group, McMaster University. GRADEpro GDT. Version (accessed prior to 10 October 2017). Hamilton (ON): GRADE Working Group, McMaster University, 2014.
Higgins 2011a
    1. Higgins JP, Altman DG, Sterne JAC, editor(s). Chapter 8: Assessing risk of bias in included studies. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
Higgins 2011b
    1. Higgins JP, Deeks JJ, Altman DG, editor(s). Chapter 16: Special topics in statistics. In: Higgins JP, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from handbook.cochrane.org.
Holekamp 2005
    1. Holekamp NM, Shui YB, Beebe DC. Vitrectomy surgery increases oxygen exposure to the lens: a possible mechanism for nuclear cataract formation. American Journal of Ophthalmology 2005;139(2):302‐10. - PubMed
Machemer 1971
    1. Machemer R, Buettner H, Norton EWD, Parel JM. Vitrectomy: a pars plana approach. Transactions of the American Academy of Ophthalmology and Otolaryngology 1971;75(4):813‐20. - PubMed
Melberg 1995
    1. Melberg NS, Thomas MA. Nuclear sclerotic cataract after vitrectomy in patients under 50 years of age. Ophthalmology 1995;102(10):1466‐71. - PubMed
Ogura 1991
    1. Ogura Y, Takanashi T, Ishigooka H, Ogino N. Quantitative analysis of lens changes after vitrectomy by fluorophotometry. American Journal of Ophthalmology 1991;111(2):179‐83. - PubMed
Palmquist 1988
    1. Palmquist BM, Philipson B, Fagerholm P. Nuclear cataract — a microradiographic study. Acta Ophthalmologica 1988;66(6):671‐7. - PubMed
Panozzo 2004
    1. Panozzo G, Parolini B. Cataracts associated with posterior segment surgery. Ophthalmology Clinics of North America 2004;17(4):557‐68. - PubMed
Pardo‐Muñoz 2006
    1. Pardo‐Muñoz A, Muriel‐Herrero A, Abraira V, Muriel A, Muñoz‐Negrete FJ, Murube J. Phacoemulsification in previously vitrectomized patients: an analysis of the surgical results in 100 eyes as well as the factors contributing to the cataract formation. European Journal of Ophthalmology 2006;16(1):52‐9. - PubMed
Review Manager 2014 [Computer program]
    1. Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager 5 (RevMan 5). Version 5.3. Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
SST 2004a
    1. Submacular Surgery Trials Research Group. Surgery for subfoveal choroidal neovascularization in age‐related macular degeneration: ophthalmic findings: SST report no. 11. Ophthalmology 2004;111(11):1967‐80. - PMC - PubMed
SST 2004b
    1. Submacular Surgery Trials Research Group. Surgery for hemorrhagic choroidal neovascular lesions of age‐related macular degeneration: ophthalmic findings. SST report no. 13. Ophthalmology 2004;111(11):1993‐2006. - PMC - PubMed
SST 2004c
    1. Submacular Surgery Trials Research Group. Surgical removal vs observation for subfoveal choroidal neovascularization, either associated with the ocular histoplasmosis syndrome or idiopathic: I. Ophthalmic findings from a randomized clinical trial: Submacular Surgery Trials (SST) Group H Trial: SST Report No. 9. Archives of Ophthalmology 2004;122(11):1597‐611. - PMC - PubMed

References to other published versions of this review

Do 2007
    1. Do DV, Hawkins BS, Gichuhi S. Surgery for post‐vitrectomy cataract. Cochrane Database of Systematic Reviews 1, Issue 2007. [DOI: 10.1002/14651858.CD006366] - DOI - PMC - PubMed
Do 2008
    1. Do DV, Hawkins B, Gichuhi S, Vedula SS. Surgery for post‐vitrectomy cataract. Cochrane Database of Systematic Reviews 2008, Issue 3. [DOI: 10.1002/14651858.CD006366.pub2] - DOI - PMC - PubMed
Do 2013
    1. Do DV, Gichuhi S, Vedula SS, Hawkins BS. Surgery for post‐vitrectomy cataract. Cochrane Database of Systematic Reviews 2013, Issue 12. [DOI: 10.1002/14651858.CD006366.pub3] - DOI - PMC - PubMed

Publication types