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Randomized Controlled Trial
. 2018 Jan 7;53(1):53-56.
doi: 10.3760/cma.j.issn.1673-0860.2018.01.012.

[Efficacy of systemic glucocorticoids combined with inhaled steroid on children with acute laryngitis]

[Article in Chinese]
Q P Chen  1 , R F Zhou  2 , Y M Zhang  1 , L Yang  1
Affiliations
Randomized Controlled Trial

[Efficacy of systemic glucocorticoids combined with inhaled steroid on children with acute laryngitis]

[Article in Chinese]
Q P Chen et al. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. .

Abstract
in English, Chinese

Objective: To evaluate the efficacy of systemic glucocorticoid (steroid) combined with high dose inhaled steroid in the treatment of children with acute laryngitis. Methods: A total of 78 children with acute laryngitis were randomly divided into study group(n=40) and control group(n=38) between November 2016 and April 2017. In addition to routine treatment of anti infection and symptomatic treatment, Dexamethasone injection(0.3-0.5 mg/kg, 1-3 d, according to the patient's condition) was provided to each group. In addition to the treatment mentioned above, the study group were assigned to receive 1.0 mg Budesonide suspension for inhalation, oxygen-driven atomizing inhalation, every/30 minutes, 2 times in a row, after that every 12 hours. The improvement of inspiratory dyspnea, hoarseness, barking cough and wheezing of both groups was evaluated at 30 min, 1 h, 2 h, 6 h, 12 h, 24 h and 72 h after treatment.Sigmaplot 11.5 software was used to analyze the data. Results: No significant difference was detected in terms of inspiratory dyspnea, hoarseness, barking cough or stridor score before treatment between the two groups(P>0.05). Compared with those before treatment, symptoms of inspiratory dyspnea, hoarseness, barking cough and stridor score of both groups improved markedly at 12 h and 24 h after treatment(P<0.05). While there was no significant difference regarding inspiratory dyspnea, hoarseness, barking cough or stridor score at each time point after treatment between the two groups(P>0.05). The effective rate was 92.50% and 92.11% in study group and control group, respectively, and no significant difference was noted (P>0.05). Conclusion: Compared with single systemic glucocorticoid, systemic glucocorticoids combined with inhaled steroid possessed similar efficacy in treating acute laryngitis and relieving laryngeal obstruction of children.

目的： 观察全身用糖皮质激素联合高剂量雾化吸入激素治疗小儿急性喉炎的疗效。 方法： 选择2016年11月至2017年4月诊断为急性喉炎儿童患者作为研究对象，采用随机数字表法将患儿分为观察组40例和对照组38例。两组患儿除常规给予抗感染及对症治疗外，均采用地塞米松磷酸钠注射液0.3～0.5 mg/kg静脉滴注，根据病情使用1～3 d；观察组在此基础上加用吸入用布地奈德混悬液1.0 mg/次，氧气驱动雾化吸入，1次/30 min，连续2次，此后每12小时1次。观察治疗后30 min、1 h、2 h、6 h、12 h、24 h两组患儿吸气性呼吸困难、声嘶、犬吠样咳嗽、喉鸣症状的改善情况及治疗72 h后的临床疗效。采用Sigmaplot 11.5软件对数据进行分析。 结果： 两组患儿治疗前呼吸困难、声嘶、犬吠样咳嗽和喉鸣评分差异均无统计学意义(P>0.05)；观察组与对照组患儿治疗12 h、24 h后呼吸困难、声嘶、犬吠样咳嗽和喉鸣评分均较治疗前下降，t值分别为3.23与7.49、3.10与7.72，差异有统计学意义(P<0.05)。两组患儿治疗后各时间段呼吸困难、声嘶、犬吠样咳嗽和喉鸣评分组间比较差异均无统计学意义(P>0.05)。观察组显效率为92.50%，对照组为92.11%，差异无统计学意义(χ(2)＝0.129，P>0.05)。 结论： 治疗小儿急性喉炎，缓解喉阻塞，全身用激素联合吸入激素与单用全身激素相比，疗效相似。.

Keywords: Children; Glucocorticoids; Ncute laryngitis; Nebulization therapy.

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