doi: 10.1016/0014-2999(85)90300-0.
Inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT receptor agonists
- PMID: 2936612
- DOI: 10.1016/0014-2999(85)90300-0
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Inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT receptor agonists
Eur J Pharmacol.
.
Abstract
We measured the inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig hippocampal membranes by 5-HT, 5-carboxamidotryptamine (CAT) and 8-hydroxy-2-(di-n-propylamino) tetralin (PAT). Low concentrations of these agonists inhibited forskolin-stimulated adenylate cyclase activity in a concentration-dependent and saturable manner. The antagonist spiperone shifted the concentration-response curve to CAT to the right in a parallel manner. The EC50 values of CAT, PAT and 5-HT and the KB of spiperone suggest that this receptor may correspond to the 5-HT1A binding site.
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