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. 1979 Nov;76(11):5601-5.
doi: 10.1073/pnas.76.11.5601.

Purification and partial characterization of human lymphoblast interferon

K C Zoon, M E Smith, P J Bridgen, D zur Nedden, C B Anfinsen

Purification and partial characterization of human lymphoblast interferon

K C Zoon et al. Proc Natl Acad Sci U S A. 1979 Nov.

Abstract

One component of human lymphoblastoid interferon obtained from Namalwa cultures induced by Newcastle disease virus has been purified to a specific activity of 2.5 x 10(8) interferon units per mg of protein (protein content based on amino acid analysis). A single polypeptide species with an apparent molecular weight of 18,500 comigrating with the antiviral activity was observed by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. Preliminary amino-terminal sequencing results support the conclusion that the interferon species is essentially homogeneous.

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