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. 2018 Nov;14(11):1080-1084.
doi: 10.1016/j.sapharm.2018.01.007. Epub 2018 Jan 31.

Reliability and validity of SF-12v2 among adults with self-reported cancer

Naleen Raj Bhandari  1 , Niranjan Kathe  1 , Corey Hayes  2 , Nalin Payakachat  3
Affiliations

Reliability and validity of SF-12v2 among adults with self-reported cancer

Naleen Raj Bhandari et al. Res Social Adm Pharm. 2018 Nov.

Abstract

Background: The SF-12v2 has been validated in general population and other conditions but the evidence is limited in Americans with cancer.

Objective: To assess reliability and validity of SF-12v2 among adults with self-reported cancer using the Medical Expenditure Panel Survey (MEPS).

Methods: Self-reported cancer participants (SCPs) were identified from 2003 MEPS. SF-12v2 was administered as part of self-administered questionnaires. Physical (PCS12) and mental (MCS12) component scores of SF-12v2 were evaluated for reliability (internal consistency, test-retest) and validity (convergent, discriminant, predictive, concurrent).

Results: 420 SCPs were identified with average age of 59.3 years (SE = 0.9). 10.7% had multiple cancers (>1) and 52% had at least one other chronic condition (OCC). Average PCS12 and MCS12 were 45.09 (SE = 0.5) and 50.75 (SE = 0.5). PCS12 and MCS12 demonstrated high internal consistency (αPCS12 = 0.89; αMCS12 = 0.88), acceptable test-retest reliability (ICCPCS12 = 0.82; ICCMCS12 = 0.73), strongly correlated with most of the expected EQ-5D domains (r = 0.51-0.71), and demonstrated strong convergent validity on perceived health (r = 0.61) and perceived mental health (r = 0.52). PCS12 and MCS12 were able to discriminate between groups with and without physical/cognitive limitations. Only PCS12 was negatively correlated with number of OCCs.

Conclusion: The SF-12v2 is a reliable and valid instrument to quantify health-related quality of life among adults with self-reported cancer.

Keywords: Cancer; Psychometrics; Quality of life; Reliability and validity; SF-12.

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Conflict of interest statement

Conflict of Interest

Dr. Hayes was supported by the Translational Training in Addiction [1T32 DA 022981]. Dr. Payakachat received an honorarium for service as a paid consultant to Roche Ltd., service as a consultant to CBPartners, and ownership of stock in Pfizer. Others authors report no conflicts of interest.

Figures

Figure 1.
Figure 1.
Graphical representation of methods used in the psychometric evaluation of SF-12v2 among patients with self-reported cancer
Figure 2.
Figure 2.
Concurrent Validity: PCS12/MCS12 vs. Number of Other Chronic Conditions
See this image and copyright information in PMC

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