The P2X7 purinergic receptor: An emerging therapeutic target in cardiovascular diseases
- PMID: 29366837
- DOI: 10.1016/j.cca.2018.01.032
The P2X7 purinergic receptor: An emerging therapeutic target in cardiovascular diseases
Abstract
The P2X7 purinergic receptor, a calcium permeable cationic channel, is activated by extracellular ATP. Most studies show that P2X7 receptor plays an important role in the nervous system diseases, immune response, osteoporosis and cancer. Mounting evidence indicates that P2X7 receptor is also associated with cardiovascular disease. For example, the P2X7 receptor activated by ATP can attenuate myocardial ischemia-reperfusion injury. By contrast, inhibition of P2X7 receptor decreases arrhythmia after myocardial infarction, prolongs cardiac survival after a long term heart transplant, alleviates the dilated cardiomyopathy and the autoimmune myocarditis process. The P2X7 receptor also mitigates vascular diseases including atherosclerosis, hypertension, thrombosis and diabetic retinopathy. This review focuses on the latest research on the role and therapeutic potential of P2X7 receptor in cardiovascular diseases.
Keywords: Atherosclerosis; Autoimmune myocarditis; Diabetic retinopathy; Dilated cardiomyopathy; Myocardial ischemia-reperfusion injury; The P2X7 receptor.
Copyright © 2018 Elsevier B.V. All rights reserved.
Similar articles
-
P2X7 receptor in cardiovascular disease: The heart side.Clin Exp Pharmacol Physiol. 2019 Jun;46(6):513-526. doi: 10.1111/1440-1681.13079. Epub 2019 Apr 7. Clin Exp Pharmacol Physiol. 2019. PMID: 30834550 Review.
-
P2X7 Receptors: An Untapped Target for the Management of Cardiovascular Disease.Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):186-199. doi: 10.1161/ATVBAHA.120.315116. Epub 2020 Oct 1. Arterioscler Thromb Vasc Biol. 2021. PMID: 32998520 Free PMC article. Review.
-
P2X7 purinergic receptor: A potential target in heart diseases (Review).Mol Med Rep. 2023 Mar;27(3):74. doi: 10.3892/mmr.2023.12961. Epub 2023 Feb 17. Mol Med Rep. 2023. PMID: 36799169
-
Altered expression of P2Y2 and P2X7 purinergic receptors in the isolated rat heart mediates ischemia-reperfusion injury.Vascul Pharmacol. 2015 Oct;73:96-103. doi: 10.1016/j.vph.2015.06.003. Epub 2015 Jun 10. Vascul Pharmacol. 2015. PMID: 26070527
-
Involvement of the P2X7 purinergic receptor in inflammation: an update of antagonists series since 2009 and their promising therapeutic potential.Curr Med Chem. 2015;22(6):713-29. doi: 10.2174/0929867322666141212120926. Curr Med Chem. 2015. PMID: 25515510 Review.
Cited by
-
Loss of function mutation in the P2X7, a ligand-gated ion channel gene associated with hypertrophic cardiomyopathy.Purinergic Signal. 2019 Jun;15(2):205-210. doi: 10.1007/s11302-019-09660-7. Epub 2019 May 31. Purinergic Signal. 2019. PMID: 31152337 Free PMC article.
-
Aerobic Exercise Inhibited P2X7 Purinergic Receptors to Improve Cardiac Remodeling in Mice With Type 2 Diabetes.Front Physiol. 2022 May 31;13:828020. doi: 10.3389/fphys.2022.828020. eCollection 2022. Front Physiol. 2022. PMID: 35711309 Free PMC article.
-
THE effect of P2X7 receptor activation on functional responses of human left internal mammary artery.Naunyn Schmiedebergs Arch Pharmacol. 2025 Feb;398(2):2027-2037. doi: 10.1007/s00210-024-03411-1. Epub 2024 Sep 3. Naunyn Schmiedebergs Arch Pharmacol. 2025. PMID: 39225832
-
The inhibitory effect of Yam polysaccharides on acrylamide-induced programmed cell death in RAW 264.7 cells.Food Sci Nutr. 2022 Sep 27;11(1):443-457. doi: 10.1002/fsn3.3076. eCollection 2023 Jan. Food Sci Nutr. 2022. PMID: 36655068 Free PMC article.
-
The Influence of Metabolic Risk Factors on the Inflammatory Response Triggered by Myocardial Infarction: Bridging Pathophysiology to Treatment.Cells. 2024 Jun 29;13(13):1125. doi: 10.3390/cells13131125. Cells. 2024. PMID: 38994977 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
