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. 2018 May:34:11-24.
doi: 10.1016/j.fsigen.2018.01.003. Epub 2018 Jan 8.

Internal validation of STRmix™ - A multi laboratory response to PCAST

Jo-Anne Bright  1 , Rebecca Richards  2 , Maarten Kruijver  2 , Hannah Kelly  2 , Catherine McGovern  2 , Alan Magee  3 , Andrew McWhorter  4 , Anne Ciecko  5 , Brian Peck  6 , Chase Baumgartner  7 , Christina Buettner  8 , Scott McWilliams  8 , Claire McKenna  9 , Colin Gallacher  10 , Ben Mallinder  10 , Darren Wright  11 , Deven Johnson  12 , Dorothy Catella  13 , Eugene Lien  14 , Craig O'Connor  14 , George Duncan  15 , Jason Bundy  16 , Jillian Echard  17 , John Lowe  18 , Joshua Stewart  19 , Kathleen Corrado  20 , Sheila Gentile  20 , Marla Kaplan  21 , Michelle Hassler  22 , Naomi McDonald  23 , Paul Hulme  24 , Rachel H Oefelein  25 , Shawn Montpetit  26 , Melissa Strong  26 , Sarah Noël  27 , Simon Malsom  28 , Steven Myers  29 , Susan Welti  30 , Tamyra Moretti  31 , Teresa McMahon  32 , Thomas Grill  33 , Tim Kalafut  34 , MaryMargaret Greer-Ritzheimer  35 , Vickie Beamer  36 , Duncan A Taylor  37 , John S Buckleton  38
Affiliations

Internal validation of STRmix™ - A multi laboratory response to PCAST

Jo-Anne Bright et al. Forensic Sci Int Genet. 2018 May.

Abstract

We report a large compilation of the internal validations of the probabilistic genotyping software STRmix™. Thirty one laboratories contributed data resulting in 2825 mixtures comprising three to six donors and a wide range of multiplex, equipment, mixture proportions and templates. Previously reported trends in the LR were confirmed including less discriminatory LRs occurring both for donors and non-donors at low template (for the donor in question) and at high contributor number. We were unable to isolate an effect of allelic sharing. Any apparent effect appears to be largely confounded with increased contributor number.

Keywords: Continuous models; Forensic DNA; PCAST; Probabilistic genotyping; STRmix; Validation.

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