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Editorial
. 2018 Feb;38(2):285-286.
doi: 10.1161/ATVBAHA.117.310493.

TRPing out Platelet Calcium: TRPM7 (Transient Receptor Potential Melastatin-Like 7) Modulates Calcium Mobilization and Platelet Function via Phospholipase C Interactions

Anh T P Ngo  1 , Owen J T McCarty  1 , Joseph E Aslan  2
Affiliations
Editorial

TRPing out Platelet Calcium: TRPM7 (Transient Receptor Potential Melastatin-Like 7) Modulates Calcium Mobilization and Platelet Function via Phospholipase C Interactions

Anh T P Ngo et al. Arterioscler Thromb Vasc Biol. 2018 Feb.
No abstract available

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Figures

Figure 1
Figure 1. TRPM7 kinase domain interacts with PLC family members to regulate intracellular Ca2+ responses and platelet function (model)
Platelet activation downstream of GPVI, CLEC-2, PARs and other receptors results in intracellular signaling events that upregulate phospholipase C (PLCγ2, PLCβ3) phosphorylation and activity to drive the metabolism of phosphatidylinositol 4,5-bisphosphate (PIP2) on the cytosolic face of the platelet plasma membrane to produce IP3 and diacylglycerol (DAG). Rather than serving as a constitutively active Mg2+/Ca2+ channel or regulating DAG-mediated receptor-operated calcium entry (ROCE) through TRP channels (TRPC) and other associated processes, this study supports a model whereby the TRPM7 kinase domain interacts with PLC family members to modulate PLC phosphorylation and activation, IP3 production, intracellular Ca2+ mobilization and STIM1-Orai1-mediated store operated calcium entry (SOCE), ultimately modulating intracellular Ca2+ concentrations and associated Ca2+ responses underlying platelet function.
See this image and copyright information in PMC

Comment on

  • TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice.
    Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A. Gotru SK, et al. Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):344-352. doi: 10.1161/ATVBAHA.117.310391. Epub 2017 Nov 16. Arterioscler Thromb Vasc Biol. 2018. PMID: 29146750

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