Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Feb;38(2):285-286.
doi: 10.1161/ATVBAHA.117.310493.

TRPing out Platelet Calcium: TRPM7 (Transient Receptor Potential Melastatin-Like 7) Modulates Calcium Mobilization and Platelet Function via Phospholipase C Interactions

Anh T P Ngo  1 , Owen J T McCarty  1 , Joseph E Aslan  2
Affiliations
Editorial

TRPing out Platelet Calcium: TRPM7 (Transient Receptor Potential Melastatin-Like 7) Modulates Calcium Mobilization and Platelet Function via Phospholipase C Interactions

Anh T P Ngo et al. Arterioscler Thromb Vasc Biol. 2018 Feb.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. TRPM7 kinase domain interacts with PLC family members to regulate intracellular Ca2+ responses and platelet function (model)
Platelet activation downstream of GPVI, CLEC-2, PARs and other receptors results in intracellular signaling events that upregulate phospholipase C (PLCγ2, PLCβ3) phosphorylation and activity to drive the metabolism of phosphatidylinositol 4,5-bisphosphate (PIP2) on the cytosolic face of the platelet plasma membrane to produce IP3 and diacylglycerol (DAG). Rather than serving as a constitutively active Mg2+/Ca2+ channel or regulating DAG-mediated receptor-operated calcium entry (ROCE) through TRP channels (TRPC) and other associated processes, this study supports a model whereby the TRPM7 kinase domain interacts with PLC family members to modulate PLC phosphorylation and activation, IP3 production, intracellular Ca2+ mobilization and STIM1-Orai1-mediated store operated calcium entry (SOCE), ultimately modulating intracellular Ca2+ concentrations and associated Ca2+ responses underlying platelet function.
See this image and copyright information in PMC

Comment on

  • TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice.
    Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A. Gotru SK, et al. Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):344-352. doi: 10.1161/ATVBAHA.117.310391. Epub 2017 Nov 16. Arterioscler Thromb Vasc Biol. 2018. PMID: 29146750

Similar articles

See all similar articles

Cited by

References

    1. Wolberg AS. Thrombin generation and fibrin clot structure. Blood Rev. 2007;21:131–142. doi: 10.1016/j.blre.2006.11.001. - DOI - PubMed
    1. Wright JH, Minot GR. THE VISCOUS METAMORPHOSIS OF THE BLOOD PLATELETS. J Exp Med. 1917;26:395–409. - PMC - PubMed
    1. Varga-Szabo D, Braun A, Nieswandt B. Calcium signaling in platelets. J Thromb Haemost. 2009;7:1057–1066. doi: 10.1111/j.1538-7836.2009.03455.x. - DOI - PubMed
    1. Li Z, Delaney MK, O’Brien KA, Du X. Signaling During Platelet Adhesion and Activation. Arterioscler Thromb Vasc Biol. 2010;30:2341–2349. doi: 10.1161/ATVBAHA.110.207522. - DOI - PMC - PubMed
    1. Aslan JE. Platelets in Thrombotic and Non-Thrombotic Disorders. Cham: Springer International Publishing; 2017. Platelet Shape Change; pp. 321–336. - DOI