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Case Reports
. 2017 May 24:4:e69.
doi: 10.14309/crj.2017.69. eCollection 2017.

Collagenous Gastritis and Helicobacter pylori Infection: A Mere Coincidence?

Daniela G Vinsard  1 , Lady Katherine Mejia Perez  1 , Aziza Nassar  1 , Maria I Vazquez Roque  1
Affiliations
Case Reports

Collagenous Gastritis and Helicobacter pylori Infection: A Mere Coincidence?

Daniela G Vinsard et al. ACG Case Rep J. .

Abstract

A 21-year-old woman presented to our clinic after 7 years of abdominal pain, diarrhea, and iron-deficiency anemia. Initial upper endoscopy revealed severe inflammation and nodularity of the gastric body and active Helicobacter pylori infection. After eradication therapy, esophagogastroduodenoscopy showed gastric atrophy with nodularity resolution. Histopathology revealed scattered plasma cells, eosinophils, and collagen deposition suggestive of collagenous gastritis. H. pylori can induce proinflammatory cytokines, resulting in fibroblast upregulation. Collagenous gastritis may be caused by an inflammatory response associated with type I, II, and III collagen. Although further research is warranted, we hypothesize that chronic inflammation from H. pylori may lead to collagenous gastritis.

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Figures

Figure 1
Figure 1
(A) EGD with narrow band imaging showing severe inflammation and erythema with active H. pylori infection. (B) EGD showing a nodular mucosa with active H. pylori infection.
Figure 2
Figure 2
EGD showing an atrophic stomach one year after H. pylori eradication.
Figure 3
Figure 3
(A) Hematoxylin and eosin stain (40x) showing an inflammatory infiltrate consisting of eosinophils (black arrow), plasma cells (red arrow), and collagen (blue arrow). (B) Masson trichrome stain (40x) showing subepithelial collagenous band measuring up to 200 μm (arrow).
See this image and copyright information in PMC

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