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Comparative Study
. 1978 Jun;20(6):676-81.

[Enzymologic study of the structural organization of the matrix or rat liver peroxisomes]

[Article in Russian]
V D Antonenkov, A M Gerasimov
  • PMID: 29368
Comparative Study

[Enzymologic study of the structural organization of the matrix or rat liver peroxisomes]

[Article in Russian]
V D Antonenkov et al. Tsitologiia. 1978 Jun.

Abstract

The effect of ionic strength and pH on the release of some enzymes of the matrix of peroxisomes in rat's liver was studied. Catalase, L ALpha-hydroxy acid oxidase, isocitrate dehydrogenase, glycerophosphate dehydrogenase and lactate dehydrogenase were easily released from the particles during their lysis and treatment with 0.16 M KCl, whereas urate oxidase, NADH cytochrome c reductase and D-amino acid oxidase were not solubilized. After the solubilization of peroxisomal membrane by 0.2% Triton X-100, the remaining core contained about 50% amino acid oxidase activity, and had 1.28--1.30 g/cm3 density. These results suggest that D-amino acid oxidase associates with urate oxidase in the peroxisomal core.

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