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. 2018 May;46(5):781-787.
doi: 10.1097/CCM.0000000000002991.

Clinical Epidemiology of Adults With Moderate Traumatic Brain Injury

Arraya Watanitanon  1 , Vivian H Lyons  2 , Abhijit V Lele  1 , Vijay Krishnamoorthy  2 , Nophanan Chaikittisilpa  1 , Theerada Chandee  1 , Monica S Vavilala  1
Affiliations

Clinical Epidemiology of Adults With Moderate Traumatic Brain Injury

Arraya Watanitanon et al. Crit Care Med. 2018 May.

Abstract

Objectives: To characterize admission patterns, treatments, and outcomes among patients with moderate traumatic brain injury.

Design: Retrospective cohort study.

Setting: National Trauma Data Bank.

Patients: Adults (age > 18 yr) with moderate traumatic brain injury (International Classification of Diseases, Ninth revision codes and admission Glasgow Coma Scale score of 9-13) in the National Trauma Data Bank between 2007 and 2014.

Interventions: None.

Measurement and main results: Demographics, mechanism of injury, hospital course, and facility characteristics were examined. Admission characteristics associated with discharge outcomes were analyzed using multivariable Poisson regression models. Of 114,066 patients, most were white (62%), male (69%), and had median admission Glasgow Coma Scale score of 12 (interquartile range, 10-13). Seventy-seven percent had isolated traumatic brain injury. Concussion, which accounted for 25% of moderate traumatic brain injury, was the most frequent traumatic brain injury diagnosis. Fourteen percent received mechanical ventilation, and 66% were admitted to ICU. Over 50% received care at a community hospital. Seven percent died, and 32% had a poor outcome, including those with Glasgow Coma Scale score of 13. Compared with patients 18-44 years, patients 45-64 years were twice as likely (adjusted relative risk, 1.97; 95% CI, 1.92-2.02) and patients over 80 years were five times as likely (adjusted relative risk, 4.66; 95% CI, 4.55-4.76) to have a poor outcome. Patients with a poor discharge outcome were more likely to have had hypotension at admission (adjusted relative risk, 1.10; 95% CI, 1.06-1.14), lower admission Glasgow Coma Scale (adjusted relative risk, 1.37; 95% CI, 1.34-1.40), higher Injury Severity Score (adjusted relative risk, 2.97; 95% CI, 2.86-3.09), and polytrauma (adjusted relative risk, 1.05; 95% CI, 1.02-1.07), compared with those without poor discharge outcomes.

Conclusions: Many patients with moderate traumatic brain injury deteriorate, require neurocritical care, and experience poor outcomes. Optimization of care and outcomes for this vulnerable group of patients are urgently needed.

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Conflict of interest statement

Conflict of interest: All authors have disclosed no potential conflict of interest.

Figures

Figure. 1
Figure. 1
Flow chart of the adult traumatic brain injury patients in National Trauma Data Bank from 2007-2014 included in the study by emergency department Glasgow Coma Scale.
Figure. 2
Figure. 2
Management of moderate traumatic brain injury stratified by polytrauma and admission Glasgow Coma Scale score. Percentage shown is of each variable within the isolated traumatic brain injury or polytrauma group.
Figure. 3
Figure. 3
Discharge disposition after moderate traumatic brain injury by admission Glasgow coma scale score (GCS) and polytrauma. Disposition data to the left of midline represents good outcome (home, transfer to other hosptial, rehabiltiation or other) and data to the right of midline represents poor otucome (Long term facility [LTC], skilled nursing facility [SNF], death or hospice).
See this image and copyright information in PMC

Comment in

  • Is "Moderate" the Correct Adjective?
    Yamamoto S, Levin HS, Robertson CS, Prough DS. Yamamoto S, et al. Crit Care Med. 2018 May;46(5):829-831. doi: 10.1097/CCM.0000000000003053. Crit Care Med. 2018. PMID: 29652715 No abstract available.
  • Optimization of Care for Adults With Moderate Traumatic Brain Injury: A Place for Transcranial Doppler.
    Esnault P, Nguyen C, Montcriol A, Prunet B, Meaudre E. Esnault P, et al. Crit Care Med. 2018 Jul;46(7):e716-e717. doi: 10.1097/CCM.0000000000003059. Crit Care Med. 2018. PMID: 29912113 No abstract available.
  • The authors reply.
    Watanitanon A, Lyons VH, Lele AV, Krishnamoorthy V, Chaikittisilpa N, Chandee T, Vavilala MS. Watanitanon A, et al. Crit Care Med. 2018 Jul;46(7):e717-e718. doi: 10.1097/CCM.0000000000003112. Crit Care Med. 2018. PMID: 29912114 No abstract available.

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